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Gene Review

MRPL3  -  mitochondrial ribosomal protein L3

Homo sapiens

Synonyms: 39S ribosomal protein L3, mitochondrial, COXPD9, L3mt, MRL3, MRP-L3, ...
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Disease relevance of MRPL3


High impact information on MRPL3

  • The protein encoded by the cDNA localizes to the nucleolus and is also found in ribosomes; possibly it is the mammalian homologue of L-3 (MRL3) [1].
  • Our data, particularly the in vitro results, suggest that the MRL-3 molecule could have an important role in the early hours of activation for the progression of resting lymphocytes into mitosis [2].


  1. Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells. Ou, J.H., Yen, T.S., Wang, Y.F., Kam, W.K., Rutter, W.J. Nucleic Acids Res. (1987) [Pubmed]
  2. Early lymphocyte activation molecule defined by the monoclonal antibody MLR-3: biochemical and functional studies. Delia, D., Traversari, C., Ballinari, D., Cattoretti, G., Fontanella, E., Polli, N., Della Porta, G. Immunology (1988) [Pubmed]
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