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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PMF1  -  polyamine-modulated factor 1

Homo sapiens

Synonyms: PMF-1, Polyamine-modulated factor 1
 
 
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Disease relevance of PMF1

  • An initial set of 101 primary frozen bladder tumors served to identify PMF1 hypermethylation in 88.1% of the cases [1].
 

High impact information on PMF1

  • The human PMF-1 gene, located on chromosome 1 near the 1q12/1q21 border, yields an mRNA transcript of approximately 1.2 kilobases that codes for a 165-amino acid protein with a predicted molecular mass of approximately 20 kDa [2].
  • Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene [2].
  • CSN 7 and PMF-1 bind to each other, as well as compete with each other for binding to Nrf-2 [3].
  • Purified PMF-1 did not bind any of the PCR fragments alone, but when added with Nrf-2, decreased the magnitude of the gel shift for one of the fragments (PRE located at -2060 relative to the transcription start site) [4].

References

  1. Identification of PMF1 methylation in association with bladder cancer progression. Aleman, A., Cebrian, V., Alvarez, M., Lopez, V., Orenes, E., Lopez-Serra, L., Algaba, F., Bellmunt, J., López-Beltrán, A., Gonzalez-Peramato, P., Cordon-Cardo, C., García, J., del Muro, J.G., Esteller, M., Sánchez-Carbayo, M. Clin. Cancer Res. (2008) [Pubmed]
  2. Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene. Wang, Y., Devereux, W., Stewart, T.M., Casero, R.A. J. Biol. Chem. (1999) [Pubmed]
  3. Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression. Wang, Y., Devereux, W., Stewart, T.M., Casero, R.A. Biochem. J. (2002) [Pubmed]
  4. Analysis of the interactions of Nrf-2, PMF-1, and CSN-7 with the 5'-flanking sequence of the mouse 4E-BP1 gene. Stephenson, A.H., Seidel, E.R. Life Sci. (2006) [Pubmed]
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