The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

PMF1  -  polyamine-modulated factor 1

Homo sapiens

Synonyms: PMF-1, Polyamine-modulated factor 1
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of PMF1

  • An initial set of 101 primary frozen bladder tumors served to identify PMF1 hypermethylation in 88.1% of the cases [1].
 

High impact information on PMF1

  • The human PMF-1 gene, located on chromosome 1 near the 1q12/1q21 border, yields an mRNA transcript of approximately 1.2 kilobases that codes for a 165-amino acid protein with a predicted molecular mass of approximately 20 kDa [2].
  • Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene [2].
  • CSN 7 and PMF-1 bind to each other, as well as compete with each other for binding to Nrf-2 [3].
  • Purified PMF-1 did not bind any of the PCR fragments alone, but when added with Nrf-2, decreased the magnitude of the gel shift for one of the fragments (PRE located at -2060 relative to the transcription start site) [4].

References

  1. Identification of PMF1 methylation in association with bladder cancer progression. Aleman, A., Cebrian, V., Alvarez, M., Lopez, V., Orenes, E., Lopez-Serra, L., Algaba, F., Bellmunt, J., López-Beltrán, A., Gonzalez-Peramato, P., Cordon-Cardo, C., García, J., del Muro, J.G., Esteller, M., Sánchez-Carbayo, M. Clin. Cancer Res. (2008) [Pubmed]
  2. Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene. Wang, Y., Devereux, W., Stewart, T.M., Casero, R.A. J. Biol. Chem. (1999) [Pubmed]
  3. Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression. Wang, Y., Devereux, W., Stewart, T.M., Casero, R.A. Biochem. J. (2002) [Pubmed]
  4. Analysis of the interactions of Nrf-2, PMF-1, and CSN-7 with the 5'-flanking sequence of the mouse 4E-BP1 gene. Stephenson, A.H., Seidel, E.R. Life Sci. (2006) [Pubmed]
 
WikiGenes - Universities