Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

PRR4 - proline rich 4 (lacrimal)

Homo sapiens

Synonyms: LPRP, Lacrimal proline-rich protein, Nasopharyngeal carcinoma-associated proline-rich protein 4, PROL4, Proline-rich protein 4

Dickinson, D.P. et al., Roca, M. et al.

Roca, Armero, Jiménez, Rodríguez-Gasén, Díaz, Martín-Comín,

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High impact information on PRR4

In contrast to other proline-rich protein genes, LPRP is expressed in the lacrimal acinar cells, and other anterior exocrine glands [1].
LPRP should be a useful marker for human lacrimal gland acinar cell function in vitro [1].
LPRP was expressed in the acinar cells of the lacrimal gland, and in the submandibular gland expression of the LPRP and PRP 1 genes was localized to the serous acini and demilunes [1].
Expression of LPRP was also detected in the human submandibular, von Ebners, sublingual, and parotid glands [1].
RESULTS: Leukocytes and platelets recovered in LPRP were not statistically different between both HES and GEL samples (leukocytes: 8.10x10/microl+/-3.82 and 7.80x10/microl+/-3.47; platelets: 411x10/microl+/-182 and 406x10/microl+/-172, respectively) [2].

Analytical, diagnostic and therapeutic context of PRR4

The cell concentration of the leukocyte-platelet-rich plasma (LPRP) achieved after blood sedimentation was analysed [2].

References

A major human lacrimal gland mRNA encodes a new proline-rich protein family member. Dickinson, D.P., Thiesse, M. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
Succinylated gelatine: an alternative to hydroxyethyl starch for labelling leukocytes with 99mTc-HMPAO. Roca, M., Armero, F., Jiménez, I., Rodríguez-Gasén, A., Díaz, C., Martín-Comín, J. Nuclear medicine communications. (2005) [Pubmed]

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