Disease relevance of XAB1

• One predicted protein has similarity to the human Cockayne syndrome protein CSA and one with human GTPase XPA binding protein XAB1 [1].

High impact information on XAB1

• We have identified a human gene encoding a novel MBD2-interacting protein (MBDin) that contains an N-terminal GTP-binding site, a putative nuclear export signal (NES), and a C-terminal acidic region [2].
• A novel cytoplasmic GTPase XAB1 interacts with DNA repair protein XPA [3].
• The deduced amino acid sequence of XAB1 consisted of 374 residues with a molecular weight of 41 kDa and an isoelectric point of 4.65 [3].

Other interactions of XAB1

• These results suggest that XAB1 is a novel cytoplasmic GTPase involved in nuclear localization of XPA [3].

Analytical, diagnostic and therapeutic context of XAB1

• Sequence analysis revealed that XAB1 has four sequence motifs G1-G4 of the GTP-binding protein family in the N-terminal half [3].
• Northern blot analysis showed that XAB1 mRNA is expressed ubiquitously, and immunofluorescence analysis revealed that XAB1 is localized mainly in the cytoplasm [3].

References