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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DDX42  -  DEAD (Asp-Glu-Ala-Asp) box helicase 42

Homo sapiens

Synonyms: ATP-dependent RNA helicase DDX42, DDX42P, DEAD box protein 42, RHELP, RNA helicase-like protein, ...
 
 
 
 
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Disease relevance of DDX42

 

High impact information on DDX42

  • Further analysis showed the different transcript levels of RNAHP, DDIT3 in patients with MDS in different stages, AML, and normal controls [1].
  • Northern blot analysis revealed that RHELP is expressed in most tissues including the liver, lung, tonsil, thymus, and muscle in addition to the pancreatic islets [2].
  • In vivo or in vitro functions of RHELP as a putative RNA helicase and its potential role as a diabetic autoantigen need to be further investigated [2].
 

Analytical, diagnostic and therapeutic context of DDX42

  • Sequence analysis of the cDNA revealed that RHELP contained DEAD sequence motif and other conserved motifs of the DEAD box protein family, indicating that RHELP is a new member of this family [2].

References

  1. Gene expression profiling of the bone marrow mononuclear cells from patients with myelodysplastic syndrome. Qian, J., Chen, Z., Wang, W., Cen, J., Xue, Y. Oncol. Rep. (2005) [Pubmed]
  2. Identification of a novel human member of the DEAD box protein family. Suk, K., Kim, S., Kim, Y.H., Oh, S.H., Lee, M.K., Kim, K.W., Kim, H.D., Seo, Y.S. Biochim. Biophys. Acta (2000) [Pubmed]
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