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MeSH Review

Anemia, Iron-Deficiency

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Disease relevance of Anemia, Iron-Deficiency


Psychiatry related information on Anemia, Iron-Deficiency


High impact information on Anemia, Iron-Deficiency

  • Using a positional cloning strategy, we identified a gene, six-transmembrane epithelial antigen of the prostate 3 (Steap3), responsible for the iron deficiency anemia in the mouse mutant nm1054 [7].
  • For any given degree of anemia, the serum concentration of immunoreactive erythropoietin was lower in this group of patients than in a group of control patients with iron-deficiency anemia (P = 0.0001) [8].
  • Acquired iron-deficiency anemia caused by an antibody against the transferrin receptor [9].
  • MAIN OUTCOME MEASURES: Iron deficiency, defined as having an abnormal value for at least 2 of 3 laboratory tests of iron status (erythrocyte protoporphyrin, transferrin saturation, or serum ferritin); and iron deficiency anemia, defined as iron deficiency plus low hemoglobin [10].
  • The prevalence of CD may be increased in certain patient groups, including the following: osteoporosis or low bone mass or iron-deficiency anemia [11].

Chemical compound and disease context of Anemia, Iron-Deficiency


Biological context of Anemia, Iron-Deficiency


Anatomical context of Anemia, Iron-Deficiency


Gene context of Anemia, Iron-Deficiency

  • The prevalence of iron deficiency anemia was lower in women who carried HFE mutations [16].
  • Microcytic anemia (mk) mice and Belgrade (b) rats have severe iron deficiency anemia due to defects in intestinal iron transport and erythroid iron utilization [26].
  • Twenty of these patients judged to have iron deficiency anemia, based on reduced serum ferritin levels, had higher serum EPO levels than did the 24 other anemic patients with normal or elevated serum ferritin levels [27].
  • The in vitro production of interleukin (IL)-1beta, IL-2, IL-6, IL-10, and tumor necrosis factor alpha (TNFalpha) by peripheral blood mononuclear cells (PBMC) from 20 patients with iron deficiency anemia (IDA) was examined before and after iron supplementation and compared to values obtained for PBMC from healthy controls [28].
  • It has been shown that serum transferrin receptor to ferritin ratios have significant predictive value for differentiating iron deficiency anemia from non-iron deficiency anemia, such as anemia of chronic disorders, whereas serum ferritin is the only significant independent predictor of iron deficiency anemia [29].

Analytical, diagnostic and therapeutic context of Anemia, Iron-Deficiency


  1. Granulopoietic and erythropoietic activity in patients with anemias of iron deficiency and chronic disease. Mahmood, T., Robinson, W.A., Kurnick, J.E., Vautrin, R. Blood (1977) [Pubmed]
  2. Erythrocyte volume distribution in normal and abnormal subjects. Bessman, J.D., Johnson, R.K. Blood (1975) [Pubmed]
  3. Serum transferrin receptor as a new index of erythropoiesis. Kohgo, Y., Niitsu, Y., Kondo, H., Kato, J., Tsushima, N., Sasaki, K., Hirayama, M., Numata, T., Nishisato, T., Urushizaki, I. Blood (1987) [Pubmed]
  4. Triple fortification of salt with microcapsules of iodine, iron, and vitamin A. Zimmermann, M.B., Wegmueller, R., Zeder, C., Chaouki, N., Biebinger, R., Hurrell, R.F., Windhab, E. Am. J. Clin. Nutr. (2004) [Pubmed]
  5. Comparative bioavailability of elemental iron powders for repair of iron deficiency anemia in rats. Studies of efficacy and toxicity of carbonyl iron. Sacks, P.V., Houchin, D.N. Am. J. Clin. Nutr. (1978) [Pubmed]
  6. Nutrition classics. The American Journal of Medicine, Volume 31, 1961. Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia. Prasad, A.S., Halsted, J.A., Nadimi, M. Nutr. Rev. (1983) [Pubmed]
  7. Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Ohgami, R.S., Campagna, D.R., Greer, E.L., Antiochos, B., McDonald, A., Chen, J., Sharp, J.J., Fujiwara, Y., Barker, J.E., Fleming, M.D. Nat. Genet. (2005) [Pubmed]
  8. Decreased erythropoietin response in patients with the anemia of cancer. Miller, C.B., Jones, R.J., Piantadosi, S., Abeloff, M.D., Spivak, J.L. N. Engl. J. Med. (1990) [Pubmed]
  9. Acquired iron-deficiency anemia caused by an antibody against the transferrin receptor. Larrick, J.W., Hyman, E.S. N. Engl. J. Med. (1984) [Pubmed]
  10. Prevalence of iron deficiency in the United States. Looker, A.C., Dallman, P.R., Carroll, M.D., Gunter, E.W., Johnson, C.L. JAMA (1997) [Pubmed]
  11. Celiac disease in patients with an affected member, type 1 diabetes, iron-deficiency, or osteoporosis? Murray, J.A. Gastroenterology (2005) [Pubmed]
  12. Effect of iron therapy on serum ferritin levels in iron-deficiency anemia. Wheby, M.S. Blood (1980) [Pubmed]
  13. Carbonyl iron therapy for iron deficiency anemia. Gordeuk, V.R., Brittenham, G.M., McLaren, C.E., Hughes, M.A., Keating, L.J. Blood (1986) [Pubmed]
  14. 'Diaphragmlike' stricture and ulcer of the colon during diclofenac treatment. Whitcomb, D.C., Martin, S.P., Trellis, D.R., Evans, B.A., Becich, M.J. Arch. Intern. Med. (1992) [Pubmed]
  15. Impaired thermoregulation and thyroid function in iron-deficiency anemia. Beard, J.L., Borel, M.J., Derr, J. Am. J. Clin. Nutr. (1990) [Pubmed]
  16. The effect of HFE genotypes on measurements of iron overload in patients attending a health appraisal clinic. Beutler, E., Felitti, V., Gelbart, T., Ho, N. Ann. Intern. Med. (2000) [Pubmed]
  17. Diagnosis of iron-deficiency anemia in the elderly. Guyatt, G.H., Patterson, C., Ali, M., Singer, J., Levine, M., Turpie, I., Meyer, R. Am. J. Med. (1990) [Pubmed]
  18. Clinical evaluation of iron deficiency. Cook, J.D. Semin. Hematol. (1982) [Pubmed]
  19. Plasma thyroid hormone kinetics are altered in iron-deficient rats. Beard, J.L., Brigham, D.E., Kelley, S.K., Green, M.H. J. Nutr. (1998) [Pubmed]
  20. The impact of varying degrees of iron nutriture on several functional consequences of iron deficiency in rats. Borel, M.J., Smith, S.H., Brigham, D.E., Beard, J.L. J. Nutr. (1991) [Pubmed]
  21. Helicobacter pylori infection, iron absorption, and gastric acid secretion in Bangladeshi children. Sarker, S.A., Davidsson, L., Mahmud, H., Walczyk, T., Hurrell, R.F., Gyr, N., Fuchs, G.J. Am. J. Clin. Nutr. (2004) [Pubmed]
  22. Effects of cadmium on in vitro and in vivo erythropoiesis: erythroid progenitor cells (CFU-E), iron, and erythropoietin in cadmium-induced iron deficiency anemia. Sakata, S., Iwami, K., Enoki, Y., Kohzuki, H., Shimizu, S., Matsuda, M., Moriyama, T. Exp. Hematol. (1988) [Pubmed]
  23. Vitamin D-deficiency rickets and myelofibrosis. Yetgin, S., Ozsoylu, S., Ruacan, S., Tekinalp, G., Sarialioğlu, F. J. Pediatr. (1989) [Pubmed]
  24. High prevalence of atrophic body gastritis in patients with unexplained microcytic and macrocytic anemia: a prospective screening study. Marignani, M., Delle Fave, G., Mecarocci, S., Bordi, C., Angeletti, S., D'Ambra, G., Aprile, M.R., Corleto, V.D., Monarca, B., Annibale, B. Am. J. Gastroenterol. (1999) [Pubmed]
  25. In vivo and in vitro iron deficiency reduces protein kinase C activity and translocation in murine splenic and purified T cells. Kuvibidila, S.R., Kitchens, D., Baliga, B.S. J. Cell. Biochem. (1999) [Pubmed]
  26. The G185R mutation disrupts function of the iron transporter Nramp2. Su, M.A., Trenor, C.C., Fleming, J.C., Fleming, M.D., Andrews, N.C. Blood (1998) [Pubmed]
  27. Suppressed serum erythropoietin response to anemia and the efficacy of recombinant erythropoietin in the anemia of rheumatoid arthritis. Takashina, N., Kondo, H., Kashiwazaki, S. J. Rheumatol. (1990) [Pubmed]
  28. In vitro cytokine production in patients with iron deficiency anemia. Bergman, M., Bessler, H., Salman, H., Siomin, D., Straussberg, R., Djaldetti, M. Clin. Immunol. (2004) [Pubmed]
  29. Transferrin receptor in tissue and serum: updated clinical significance of soluble receptor. Kohgo, Y., Torimoto, Y., Kato, J. Int. J. Hematol. (2002) [Pubmed]
  30. Estimates of iron sufficiency in the US population. Cook, J.D., Skikne, B.S., Lynch, S.R., Reusser, M.E. Blood (1986) [Pubmed]
  31. Anemia vs iron deficiency: increased risk of preterm delivery in a prospective study. Scholl, T.O., Hediger, M.L., Fischer, R.L., Shearer, J.W. Am. J. Clin. Nutr. (1992) [Pubmed]
  32. Iron-deficiency anemia is associated with high concentrations of transferrin receptor in serum. Punnonen, K., Irjala, K., Rajamäki, A. Clin. Chem. (1994) [Pubmed]
  33. Intravenous iron sucrose versus oral iron supplementation for the treatment of iron deficiency anemia in patients with inflammatory bowel disease--a randomized, controlled, open-label, multicenter study. Schröder, O., Mickisch, O., Seidler, U., de Weerth, A., Dignass, A.U., Herfarth, H., Reinshagen, M., Schreiber, S., Junge, U., Schrott, M., Stein, J. Am. J. Gastroenterol. (2005) [Pubmed]
  34. Pregnancy following gastric bypass surgery for morbid obesity. Gurewitsch, E.D., Smith-Levitin, M., Mack, J. Obstetrics and gynecology. (1996) [Pubmed]
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