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CHRM5  -  cholinergic receptor, muscarinic 5

Homo sapiens

Synonyms: Muscarinic acetylcholine receptor M5
 
 
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Disease relevance of CHRM5

  • We have examined the antitumor activity of carbetimer in vivo and in vitro against HM5-Carb/S and M21, both primary human melanoma cell lines sensitive and resistant to carbetimer, respectively [1].
  • The substitution of Lys for Thr at position 18 and 19 of HP(2-9)-ME(1-12) (HM5) increased activity against Proteus vulgaris and fungal strains without hemolysis [2].
 

High impact information on CHRM5

  • We typed polymorphisms in CHRM5 and alpha7-nicotinic receptor (CHRNA7) genes on 15q13 in 82 Canadian families having at least 1 schizophrenic patient [3].
  • In rodents, the M5 muscarinic receptor (CHRM5) is important for prolonged dopamine release [3].
 

Other interactions of CHRM5

  • Our present study provided the first line of direct evidence suggesting that the CHRM5 gene combined with the CHRNA7 gene may be linked to schizophrenia [3].

References

  1. Mechanism of action of a new antitumor agent, carbetimer. Ardalan, B., Paget, G.E. Cancer Res. (1986) [Pubmed]
  2. Design of novel analogues with potent antibiotic activity based on the antimicrobial peptide, HP(2-9)-ME(1-12). Park, Y., Kim, H.N., Park, S.N., Jang, S.H., Choi, C.H., Lim, H.T., Hahm, K.S. Biotechnol. Lett. (2004) [Pubmed]
  3. Linkage of M5 muscarinic and alpha7-nicotinic receptor genes on 15q13 to schizophrenia. De Luca, V., Wang, H., Squassina, A., Wong, G.W., Yeomans, J., Kennedy, J.L. Neuropsychobiology (2004) [Pubmed]
 
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