Gene Review:
Chrm5 - cholinergic receptor, muscarinic 5
Mus musculus
Synonyms:
AChR-M5, M5R, Muscarinic acetylcholine receptor M5, m5, muscarinic acetylcholine receptor 5
- Deletion of the M5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia. Basile, A.S., Fedorova, I., Zapata, A., Liu, X., Shippenberg, T., Duttaroy, A., Yamada, M., Wess, J. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice. Yamada, M., Lamping, K.G., Duttaroy, A., Zhang, W., Cui, Y., Bymaster, F.P., McKinzie, D.L., Felder, C.C., Deng, C.X., Faraci, F.M., Wess, J. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Tumor-suppressor function of muscarinic acetylcholine receptors is associated with activation of receptor-operated calcium influx. Felder, C.C., MacArthur, L., Ma, A.L., Gusovsky, F., Kohn, E.C. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes. Gutkind, J.S., Novotny, E.A., Brann, M.R., Robbins, K.C. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Loss of M(5) muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice. Araya, R., Noguchi, T., Yuhki, M., Kitamura, N., Higuchi, M., Saido, T.C., Seki, K., Itohara, S., Kawano, M., Tanemura, K., Takashima, A., Yamada, K., Kondoh, Y., Kanno, I., Wess, J., Yamada, M. Neurobiol. Dis. (2006)
- Amino acid side chains that define muscarinic receptor/G-protein coupling. Studies of the third intracellular loop. Burstein, E.S., Spalding, T.A., Brann, M.R. J. Biol. Chem. (1996)
- Tyrosine kinase activation by the angiotensin II receptor in the absence of calcium signaling. Doan, T.N., Ali, M.S., Bernstein, K.E. J. Biol. Chem. (2001)
- Transforming G protein-coupled receptors transduce potent mitogenic signals in NIH 3T3 cells independent on cAMP inhibition or conventional protein kinase C. Stephens, E.V., Kalinec, G., Brann, M.R., Gutkind, J.S. Oncogene (1993)
- Constitutive activation of the m5 muscarinic receptor by a series of mutations at the extracellular end of transmembrane 6. Spalding, T.A., Burstein, E.S., Wells, J.W., Brann, M.R. Biochemistry (1997)
- Stereoselective increase in cholinergic transmission by R-(+)-hyoscyamine. Ghelardini, C., Gualtieri, F., Novella Romanelli, M., Angeli, P., Pepeu, G., Grazia Giovannini, M., Casamenti, F., Malmberg-Aiello, P., Giotti, A., Bartolini, A. Neuropharmacology (1997)
- Structure of a G-protein-coupling domain of a muscarinic receptor predicted by random saturation mutagenesis. Hill-Eubanks, D., Burstein, E.S., Spalding, T.A., Bräuner-Osborne, H., Brann, M.R. J. Biol. Chem. (1996)
- Decreased amphetamine-induced locomotion and improved latent inhibition in mice mutant for the M5 muscarinic receptor gene found in the human 15q schizophrenia region. Wang, H., Ng, K., Hayes, D., Gao, X., Forster, G., Blaha, C., Yeomans, J. Neuropsychopharmacology (2004)
- Human muscarinic receptors expressed in A9L and CHO cells: activation by full and partial agonists. Richards, M.H., van Giersbergen, P.L. Br. J. Pharmacol. (1995)
- Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice. Zhang, W., Yamada, M., Gomeza, J., Basile, A.S., Wess, J. J. Neurosci. (2002)
- Delineation of muscarinic receptor domains conferring selectivity of coupling to guanine nucleotide-binding proteins and second messengers. Wess, J., Bonner, T.I., Dörje, F., Brann, M.R. Mol. Pharmacol. (1990)
- Reduced cocaine self-administration in muscarinic M5 acetylcholine receptor-deficient mice. Thomsen, M., Woldbye, D.P., Wörtwein, G., Fink-Jensen, A., Wess, J., Caine, S.B. J. Neurosci. (2005)
- Analysis of muscarinic receptor subtypes in the mouse cochlea by means of the polymerase chain reaction. Drescher, D.G., Upadhyay, S., Wilcox, E., Fex, J. J. Neurochem. (1992)
- Modulation of low-threshold T-type calcium channels by the five muscarinic receptor subtypes in NIH 3T3 cells. Pemberton, K.E., Hill-Eubanks, L.J., Jones, S.V. Pflugers Arch. (2000)