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Gene Review

Inpp5e  -  inositol polyphosphate-5-phosphatase E

Rattus norvegicus

Synonyms: 5-phosphatase that induces arborization, 72 kDa inositol polyphosphate 5-phosphatase, Pharbin, Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, Phosphatidylinositol polyphosphate 5-phosphatase type IV
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High impact information on Inpp5e

  • Thus, pharbin indeed serves as an inositol polyphosphate 5-phosphatase [1].
  • When pharbin was transfected to C3H/10T1/2 fibroblasts, it was located to the plasma membrane-associated structures including membrane ruffles [1].
  • COS-7 cells transfected with pharbin exhibited elevated hydrolytic activity on the 5-phosphate group of inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, and phosphatidylinositol 4, 5-bisphosphate [1].
  • Pharbin contains relatively well-conserved catalytic motifs for 5-phosphatase, a proline-rich sequence corresponding to the SH3-binding motif, and a sequence consistent with the CaaX motif at the C-terminus [1].


  1. Pharbin, a novel inositol polyphosphate 5-phosphatase, induces dendritic appearances in fibroblasts. Asano, T., Mochizuki, Y., Matsumoto, K., Takenawa, T., Endo, T. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
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