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Gene Review

Inpp5e  -  inositol polyphosphate-5-phosphatase E

Mus musculus

Synonyms: 1200002L24Rik, 72 kDa inositol polyphosphate 5-phosphatase, 72kDa, Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, Phosphatidylinositol polyphosphate 5-phosphatase type IV, ...
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Disease relevance of Inpp5e

  • The pathogenesis of Lowe syndrome due to deficiency of a phosphatidylinositol 4,5-bisphosphate 5-phosphatase in the Golgi complex is unknown [1].

High impact information on Inpp5e


  1. Functional overlap between murine Inpp5b and Ocrl1 may explain why deficiency of the murine ortholog for OCRL1 does not cause Lowe syndrome in mice. Jänne, P.A., Suchy, S.F., Bernard, D., MacDonald, M., Crawley, J., Grinberg, A., Wynshaw-Boris, A., Westphal, H., Nussbaum, R.L. J. Clin. Invest. (1998) [Pubmed]
  2. Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane. Kong, A.M., Horan, K.A., Sriratana, A., Bailey, C.G., Collyer, L.J., Nandurkar, H.H., Shisheva, A., Layton, M.J., Rasko, J.E., Rowe, T., Mitchell, C.A. Mol. Cell. Biol. (2006) [Pubmed]
  3. The increased ecto-5'-nucleotidase activity in muscle, heart and liver of laminin alpha2-deficient mice is not caused by an elevation in the mRNA content. Morote-García, J.C., Sánchez Del Campo, L.F., Campoy, F.J., Vidal, C.J., Muñoz-Delgado, E. Int. J. Biochem. Cell Biol. (2006) [Pubmed]
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