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Gene Review

Prp2l1  -  proline rich protein 2-like 1

Rattus norvegicus

Synonyms: PRP, PRP-2, Prp-5, Prp2l2
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Disease relevance of PRP-2


High impact information on PRP-2


Chemical compound and disease context of PRP-2

  • This same regimen of beta-receptor agonists was unable to induce submandibular gland hypertrophy, PRP or glycoprotein biosynthesis in the same animals [11].
  • Reperfusion of the rat hearts (at 30 min ischemia) was followed by partial recovery of PCr (44 +/- 3%) and Na+i (234 +/- 69%) and poorer recovery of the pressure-rate product (PRP, 9 +/- 4%) and end-diastolic pressure (EDP, 72 +/- 5 mmHg) compared to the pig hearts (PCr, 106 +/- 25%; Na+i, 82 +/- 17%; PRP, 24 +/- 3%; EDP, 4.6 +/- 2.5 mmHg) [12].
  • These results may be related to the ability of the glutamine/proline-rich protein PQE-1 to protect C. elegans against polyglutamine toxicity [13].

Biological context of PRP-2

  • The high degree of conservation of both nucleotide and amino acid sequence in the entire unit also indicates that the PRP gene(s) likely evolved by multiplication of a 300-base pair ancestral DNA sequence [14].
  • This oligonucleotide was used as an efficient primer for the construction of a PRP-specific lambda gt10 cDNA library [14].
  • The 4.4-kilodalton proline-rich polypeptides of the rat ventral prostate are the proteolytic products of a 637-kilodalton protein displaying highly repetitive sequences and encoded in a single exon [15].
  • Deletion of the TBM affects transcriptional activity slightly, but it is adjacent to a proline-rich sequence which constitutes the major transactivation domain [16].
  • Both proteins contain COOH-terminal proline-rich domains that can interact with a variety of Src homology 3 (SH3) domains [17].

Anatomical context of PRP-2


Associations of PRP-2 with chemical compounds


Physical interactions of PRP-2

  • We have recently identified the ubiquitin-protein ligase Nedd4 as an interacting protein with ENaC and demonstrated that Nedd4 binds by its WW domains to the proline-rich PY motifs of ENaC [22].

Regulatory relationships of PRP-2


Other interactions of PRP-2


Analytical, diagnostic and therapeutic context of PRP-2


  1. Clones from the human gene complex coding for salivary proline-rich proteins. Azen, E., Lyons, K.M., McGonigal, T., Barrett, N.L., Clements, L.S., Maeda, N., Vanin, E.F., Carlson, D.M., Smithies, O. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  2. Regulation of proline-rich protein and alpha-amylase genes in parotid-hepatoma hybrid cells. Wright, P.S., Carlson, D.M. FASEB J. (1988) [Pubmed]
  3. Isoprenaline-induced changes in rat parotid and submandibular glands are age- and dosage-dependent. Humphreys-Beher, M.G. Biochem. J. (1984) [Pubmed]
  4. Effect of new synthetic heparin mimetics on whole blood thrombin generation in vivo and in vitro in rats. Hérault, J.P., Bernat, A., Gaich, C., Herbert, M. Thromb. Haemost. (2002) [Pubmed]
  5. Selective temporal and regional alterations of Nogo-A and small proline-rich repeat protein 1A (SPRR1A) but not Nogo-66 receptor (NgR) occur following traumatic brain injury in the rat. Marklund, N., Fulp, C.T., Shimizu, S., Puri, R., McMillan, A., Strittmatter, S.M., McIntosh, T.K. Exp. Neurol. (2006) [Pubmed]
  6. Identification of a ten-amino acid proline-rich SH3 binding site. Ren, R., Mayer, B.J., Cicchetti, P., Baltimore, D. Science (1993) [Pubmed]
  7. RIM binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to voltage-gated Ca(2+) channels. Hibino, H., Pironkova, R., Onwumere, O., Vologodskaia, M., Hudspeth, A.J., Lesage, F. Neuron (2002) [Pubmed]
  8. Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition. Beneken, J., Tu, J.C., Xiao, B., Nuriya, M., Yuan, J.P., Worley, P.F., Leahy, D.J. Neuron (2000) [Pubmed]
  9. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Tu, J.C., Xiao, B., Yuan, J.P., Lanahan, A.A., Leoffert, K., Li, M., Linden, D.J., Worley, P.F. Neuron (1998) [Pubmed]
  10. Crystal structure of the amphiphysin-2 SH3 domain and its role in the prevention of dynamin ring formation. Owen, D.J., Wigge, P., Vallis, Y., Moore, J.D., Evans, P.R., McMahon, H.T. EMBO J. (1998) [Pubmed]
  11. Analysis of protein synthesis in rat salivary glands after chronic treatment with beta-receptor agonists and phosphodiesterase inhibitors. Wells, D.J., Humphreys-Beher, M.G. Biochem. Pharmacol. (1985) [Pubmed]
  12. Energy metabolism, intracellular Na+ and contractile function in isolated pig and rat hearts during cardioplegic ischemia and reperfusion: 23Na- and 31P-NMR studies. Kupriyanov, V.V., Xiang, B., Butler, K.W., St-Jean, M., Deslauriers, R. Basic Res. Cardiol. (1995) [Pubmed]
  13. Inhibition of polyglutamine aggregate cytotoxicity by a structure-based elongation inhibitor. Thakur, A.K., Yang, W., Wetzel, R. FASEB J. (2004) [Pubmed]
  14. A single 12.5-kilobase androgen-regulated mRNA encoding multiple proline-rich polypeptides in the ventral prostate of the rat. Hemschoote, K., Peeters, B., Dirckx, L., Claessens, F., De Clercq, N., Heyns, W., Winderickx, J., Bannwarth, W., Rombauts, W. J. Biol. Chem. (1988) [Pubmed]
  15. The 4.4-kilodalton proline-rich polypeptides of the rat ventral prostate are the proteolytic products of a 637-kilodalton protein displaying highly repetitive sequences and encoded in a single exon. De Clercq, N., Hemschoote, K., Devos, A., Peeters, B., Heyns, W., Rombauts, W. J. Biol. Chem. (1992) [Pubmed]
  16. A C-terminal domain in FosB, absent in FosB/SF and Fra-1, which is able to interact with the TATA binding protein, is required for altered cell growth. Metz, R., Kouzarides, T., Bravo, R. EMBO J. (1994) [Pubmed]
  17. The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain. Ringstad, N., Nemoto, Y., De Camilli, P. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  18. Modulation of proline-rich protein biosynthesis in rat parotid glands by sorghums with high tannin levels. Mehansho, H., Hagerman, A., Clements, S., Butler, L., Rogler, J., Carlson, D.M. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  19. A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function. Catling, A.D., Schaeffer, H.J., Reuter, C.W., Reddy, G.R., Weber, M.J. Mol. Cell. Biol. (1995) [Pubmed]
  20. Induction of proline-rich glycoprotein synthesis in mouse salivary glands by isoproterenol and by tannins. Mehansho, H., Clements, S., Sheares, B.T., Smith, S., Carlson, D.M. J. Biol. Chem. (1985) [Pubmed]
  21. Solution structure of a Nedd4 WW domain-ENaC peptide complex. Kanelis, V., Rotin, D., Forman-Kay, J.D. Nat. Struct. Biol. (2001) [Pubmed]
  22. Immunolocalization of the ubiquitin-protein ligase Nedd4 in tissues expressing the epithelial Na+ channel (ENaC). Staub, O., Yeger, H., Plant, P.J., Kim, H., Ernst, S.A., Rotin, D. Am. J. Physiol. (1997) [Pubmed]
  23. Phosphospecific site tyrosine phosphorylation of p125FAK and proline-rich kinase 2 is differentially regulated by cholecystokinin receptor type A activation in pancreatic acini. Pace, A., García-Marin, L.J., Tapia, J.A., Bragado, M.J., Jensen, R.T. J. Biol. Chem. (2003) [Pubmed]
  24. Synamon, a novel neuronal protein interacting with synapse-associated protein 90/postsynaptic density-95-associated protein. Yao, I., Hata, Y., Hirao, K., Deguchi, M., Ide, N., Takeuchi, M., Takai, Y. J. Biol. Chem. (1999) [Pubmed]
  25. NMR structures of 36 and 73-residue fragments of the calreticulin P-domain. Ellgaard, L., Bettendorff, P., Braun, D., Herrmann, T., Fiorito, F., Jelesarov, I., Güntert, P., Helenius, A., Wüthrich, K. J. Mol. Biol. (2002) [Pubmed]
  26. Calcium-independent activation of extracellularly regulated kinases 1 and 2 by angiotensin II in hepatic C9 cells: roles of protein kinase Cdelta, Src/proline-rich tyrosine kinase 2, and epidermal growth receptor trans-activation. Shah, B.H., Catt, K.J. Mol. Pharmacol. (2002) [Pubmed]
  27. The role of the Ca2+-sensitive tyrosine kinase Pyk2 and Src in thrombin signalling in rat astrocytes. Wang, H., Reiser, G. J. Neurochem. (2003) [Pubmed]
  28. Induction of tissue-specific proline-rich protein multigene families in rat and mouse parotid glands by isoproterenol. Unusual strain differences of proline-rich protein mRNAs. Ann, D.K., Clements, S., Johnstone, E.M., Carlson, D.M. J. Biol. Chem. (1987) [Pubmed]
  29. Reduced platelet aggregability and increased vascular prostacyclin formation in a variant rat strain (IVA-SIV) with endogenous hypertriglyceridemia. Lovati, M.R., Manzoni, C., Mosconi, C., Colli, S., Sirtori, C.R., Fumagalli, G., Clementi, F. Atherosclerosis (1988) [Pubmed]
  30. Elimination of isoproterenol-induced proline-rich protein biosynthesis in rat salivary glands after adult thyroidectomy. Humphreys-Beher, M.G. Biochem. Pharmacol. (1987) [Pubmed]
  31. The effects of autonomic drugs on the concentration of kallikrein-like proteases and cysteine-proteinase inhibitor (cystatin) in rat whole saliva. Bedi, G.S. J. Dent. Res. (1991) [Pubmed]
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