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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Npnt  -  nephronectin

Mus musculus

Synonyms: 1110009H02Rik, AA682063, AI314031, Nctn, Neph1, ...
 
 
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High impact information on Npnt

  • Nephronectin mRNA is expressed in the ureteric bud epithelium, whereas alpha8beta1 is expressed in the metanephric mesenchyme [1].
  • Integrin alpha8beta1 and several additional RGD-binding integrins bind nephronectin [1].
 

Associations of Npnt with chemical compounds

  • Our results thus place nephronectin and alpha8beta1 integrin in a pathway that regulates Gdnf expression and is essential for kidney development [2].

References

  1. Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney. Brandenberger, R., Schmidt, A., Linton, J., Wang, D., Backus, C., Denda, S., Müller, U., Reichardt, L.F. J. Cell Biol. (2001) [Pubmed]
  2. The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression. Linton, J.M., Martin, G.R., Reichardt, L.F. Development (2007) [Pubmed]
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