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Gene Review

NPNT  -  nephronectin

Homo sapiens

Synonyms: EGFL6L, Nephronectin, POEM, Preosteoblast EGF-like repeat protein with MAM domain, Protein EGFL6-like, ...


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High impact information on NPNT

  • Nephronectin is a new extracellular matrix protein associated with the Wolffian duct and the ureteric bud, epithelial structures with well-defined roles in kidney development [1].
  • In adults, the NPNT expression was widely found in lung, kidney, brain, uterus, placenta, thyroid gland and blood vessels [2].
  • Lubrication properties were compared among glycerin fatty acid esters (Poem TR-FB and Poem TR-HB), magnesium stearate (Mg-St), and a sucrose fatty acid ester (RYOTO SUGAR ESTER S-370F: SSE) [3].
  • Nephronectin is a Wnt target gene; epidermal β-catenin activation upregulates epidermal nephronectin and dermal α8 integrin expression.  [4]
  • Nephronectin induces α8 integrin-positive cells to upregulate smooth muscle markers. [4]


  1. Mystery solved: discovery of a novel integrin ligand in the developing kidney. Miner, J.H. J. Cell Biol. (2001) [Pubmed]
  2. Identification and characterization of a novel human nephronectin gene in silico. Huang, J.T., Lee, V. Int. J. Mol. Med. (2005) [Pubmed]
  3. Glycerin fatty acid esters as a new lubricant of tablets. Aoshima, H., Miyagisnima, A., Nozawa, Y., Sadzuka, Y., Sonobe, T. International journal of pharmaceutics. (2005) [Pubmed]
  4. The basement membrane of hair follicle stem cells is a muscle cell niche. Fujiwara, H., Ferreira, M., Donati, G., Marciano, D.K., Linton, J.M., Sato, Y., Hartner, A., Sekiguchi, K., Reichardt, L.F., Watt, F.M. Cell. (2011) [Pubmed]
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