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Gene Review

Gdnf  -  glial cell line derived neurotrophic factor

Mus musculus

Synonyms: AI385739, ATF, Astrocyte-derived trophic factor, Glial cell line-derived neurotrophic factor, glial cell line-derived neurotrophic factor, ...
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Disease relevance of Gdnf


Psychiatry related information on Gdnf


High impact information on Gdnf


Chemical compound and disease context of Gdnf


Biological context of Gdnf

  • This Gdnf(+/-) mutant cohort recapitulates complex features characteristic of HSCR, including dominant inheritance, incomplete penetrance, and variable severity of symptoms [1].
  • The lack of one functioning Gdnf allele causes a spectrum of defects in gastrointestinal motility and predisposes the mutant mice to HSCR-like phenotypes [1].
  • The experimentally induced dysmorphology associated with deregulated expression of Wnt11, Gdnf and Fgf7 genes in the early stages of organogenesis indicated a crucial role for sprouty function in coordination of epithelial-mesenchymal and stromal signalling, the sites of expression of these genes [17].
  • These findings uncover an essential function for Eya 1 as a critical determination factor in acquiring metanephric fate within the intermediate mesoderm and as a key regulator of Gdnf expression during ureteric induction and branching morphogenesis [18].
  • The architecture of the binding sites in the Six2 promoter, but not the binding sequence itself, is very similar to the one in the Gdnf promoter [19].

Anatomical context of Gdnf


Associations of Gdnf with chemical compounds


Physical interactions of Gdnf


Regulatory relationships of Gdnf


Other interactions of Gdnf


Analytical, diagnostic and therapeutic context of Gdnf


  1. Gdnf haploinsufficiency causes Hirschsprung-like intestinal obstruction and early-onset lethality in mice. Shen, L., Pichel, J.G., Mayeli, T., Sariola, H., Lu, B., Westphal, H. Am. J. Hum. Genet. (2002) [Pubmed]
  2. Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo. Malin, S.A., Molliver, D.C., Koerber, H.R., Cornuet, P., Frye, R., Albers, K.M., Davis, B.M. J. Neurosci. (2006) [Pubmed]
  3. Glial cell line-derived neurotrophic factor differentially stimulates ret mutants associated with the multiple endocrine neoplasia type 2 syndromes and Hirschsprung's disease. Carlomagno, F., Melillo, R.M., Visconti, R., Salvatore, G., De Vita, G., Lupoli, G., Yu, Y., Jing, S., Vecchio, G., Fusco, A., Santoro, M. Endocrinology (1998) [Pubmed]
  4. Marked dopaminergic cell loss subsequent to developmental, intranigral expression of glial cell line-derived neurotrophic factor. Chun, H.S., Yoo, M.S., DeGiorgio, L.A., Volpe, B.T., Peng, D., Baker, H., Peng, C., Son, J.H. Exp. Neurol. (2002) [Pubmed]
  5. Impaired water maze learning performance without altered dopaminergic function in mice heterozygous for the GDNF mutation. Gerlai, R., McNamara, A., Choi-Lundberg, D.L., Armanini, M., Ross, J., Powell-Braxton, L., Phillips, H.S. Eur. J. Neurosci. (2001) [Pubmed]
  6. The noradrenergic system of aged GDNF heterozygous mice. Zaman, V., Li, Z., Middaugh, L., Ramamoorthy, S., Rohrer, B., Nelson, M.E., Tomac, A.C., Hoffer, B.J., Gerhardt, G.A., Granholm, A.C.h. Cell transplantation. (2003) [Pubmed]
  7. Glial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol consumption. He, D.Y., McGough, N.N., Ravindranathan, A., Jeanblanc, J., Logrip, M.L., Phamluong, K., Janak, P.H., Ron, D. J. Neurosci. (2005) [Pubmed]
  8. RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice. Jain, S., Golden, J.P., Wozniak, D., Pehek, E., Johnson, E.M., Milbrandt, J. J. Neurosci. (2006) [Pubmed]
  9. Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's disease. McBride, J.L., Ramaswamy, S., Gasmi, M., Bartus, R.T., Herzog, C.D., Brandon, E.P., Zhou, L., Pitzer, M.R., Berry-Kravis, E.M., Kordower, J.H. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  10. Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Xu, P.X., Adams, J., Peters, H., Brown, M.C., Heaney, S., Maas, R. Nat. Genet. (1999) [Pubmed]
  11. GDNF signalling through the Ret receptor tyrosine kinase. Durbec, P., Marcos-Gutierrez, C.V., Kilkenny, C., Grigoriou, M., Wartiowaara, K., Suvanto, P., Smith, D., Ponder, B., Costantini, F., Saarma, M. Nature (1996) [Pubmed]
  12. Renal and neuronal abnormalities in mice lacking GDNF. Moore, M.W., Klein, R.D., Fariñas, I., Sauer, H., Armanini, M., Phillips, H., Reichardt, L.F., Ryan, A.M., Carver-Moore, K., Rosenthal, A. Nature (1996) [Pubmed]
  13. Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Sánchez, M.P., Silos-Santiago, I., Frisén, J., He, B., Lira, S.A., Barbacid, M. Nature (1996) [Pubmed]
  14. Astrocyte delivery of glial cell line-derived neurotrophic factor in a mouse model of Parkinson's disease. Cunningham, L.A., Su, C. Exp. Neurol. (2002) [Pubmed]
  15. GDNF as a candidate striatal target-derived neurotrophic factor for the development of substantia nigra dopamine neurons. Burke, R.E. J. Neural Transm. Suppl. (2006) [Pubmed]
  16. Protection by synergistic effects of adenovirus-mediated X-chromosome-linked inhibitor of apoptosis and glial cell line-derived neurotrophic factor gene transfer in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Eberhardt, O., Coelln, R.V., Kugler, S., Lindenau, J., Rathke-Hartlieb, S., Gerhardt, E., Haid, S., Isenmann, S., Gravel, C., Srinivasan, A., Bahr, M., Weller, M., Dichgans, J., Schulz, J.B. J. Neurosci. (2000) [Pubmed]
  17. Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development. Chi, L., Zhang, S., Lin, Y., Prunskaite-Hyyryläinen, R., Vuolteenaho, R., Itäranta, P., Vainio, S. Development (2004) [Pubmed]
  18. Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Sajithlal, G., Zou, D., Silvius, D., Xu, P.X. Dev. Biol. (2005) [Pubmed]
  19. The transcription factor Six2 activates expression of the Gdnf gene as well as its own promoter. Brodbeck, S., Besenbeck, B., Englert, C. Mech. Dev. (2004) [Pubmed]
  20. Glial cell line-derived neurotrophic factor promotes the development of adrenergic neurons in mouse neural crest cultures. Maxwell, G.D., Reid, K., Elefanty, A., Bartlett, P.F., Murphy, M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  21. Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons. Holm, P.C., Rodríguez, F.J., Kresse, A., Canals, J.M., Silos-Santiago, I., Arenas, E. Development (2003) [Pubmed]
  22. Glial cell-line derived neurotrophic factor-mediated RET signaling regulates spermatogonial stem cell fate. Naughton, C.K., Jain, S., Strickland, A.M., Gupta, A., Milbrandt, J. Biol. Reprod. (2006) [Pubmed]
  23. Focal expression of glial cell line-derived neurotrophic factor in developing mouse limb bud. Wright, D.E., Snider, W.D. Cell Tissue Res. (1996) [Pubmed]
  24. Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Majumdar, A., Vainio, S., Kispert, A., McMahon, J., McMahon, A.P. Development (2003) [Pubmed]
  25. Localization of nerve growth factor, neurotrophin-3, and glial cell line-derived neurotrophic factor in nestin-expressing reactive astrocytes in the caudate-putamen of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57/Bl mice. Chen, L.W., Zhang, J.P., Kwok-Yan Shum, D., Chan, Y.S. J. Comp. Neurol. (2006) [Pubmed]
  26. Glial cell line-derived neurotrophic factor-responsive and neurotrophin-3-responsive neurons require the cytoskeletal linker protein dystonin for postnatal survival. Carlsten, J.A., Kothary, R., Wright, D.E. J. Comp. Neurol. (2001) [Pubmed]
  27. Glial cell line-derived neurotrophic factor protects midbrain dopamine neurons from the lethal action of the weaver gene: a quantitative immunocytochemical study. Broome, J.D., Wills, K.V., Lapchak, P.A., Ghetti, B., Camp, L.L., Bayer, S.A. Brain Res. Dev. Brain Res. (1999) [Pubmed]
  28. Nephron endowment in glial cell line-derived neurotrophic factor (GDNF) heterozygous mice. Cullen-McEwen, L.A., Drago, J., Bertram, J.F. Kidney Int. (2001) [Pubmed]
  29. Impaired behavioural flexibility and memory in mice lacking GDNF family receptor alpha2. Võikar, V., Rossi, J., Rauvala, H., Airaksinen, M.S. Eur. J. Neurosci. (2004) [Pubmed]
  30. Sensitization of transient receptor potential vanilloid 1 by the prokineticin receptor agonist Bv8. Vellani, V., Colucci, M., Lattanzi, R., Giannini, E., Negri, L., Melchiorri, P., McNaughton, P.A. J. Neurosci. (2006) [Pubmed]
  31. Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse. Frasson, M., Picaud, S., Léveillard, T., Simonutti, M., Mohand-Said, S., Dreyfus, H., Hicks, D., Sabel, J. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  32. Activation of BMK1 via tyrosine 1062 in RET by GDNF and MEN2A mutation. Hayashi, Y., Iwashita, T., Murakamai, H., Kato, Y., Kawai, K., Kurokawa, K., Tohnai, I., Ueda, M., Takahashi, M. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  33. Hox11 paralogous genes are essential for metanephric kidney induction. Wellik, D.M., Hawkes, P.J., Capecchi, M.R. Genes Dev. (2002) [Pubmed]
  34. GDNF availability determines enteric neuron number by controlling precursor proliferation. Gianino, S., Grider, J.R., Cresswell, J., Enomoto, H., Heuckeroth, R.O. Development (2003) [Pubmed]
  35. Neurturin and glial cell line-derived neurotrophic factor receptor-beta (GDNFR-beta), novel proteins related to GDNF and GDNFR-alpha with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in peripheral organs. Widenfalk, J., Nosrat, C., Tomac, A., Westphal, H., Hoffer, B., Olson, L. J. Neurosci. (1997) [Pubmed]
  36. Regulation of metanephric kidney development by growth/differentiation factor 11. Esquela, A.F., Lee, S.J. Dev. Biol. (2003) [Pubmed]
  37. Overexpression of glial cell line-derived neurotrophic factor in the CNS rescues motoneurons from programmed cell death and promotes their long-term survival following axotomy. Zhao, Z., Alam, S., Oppenheim, R.W., Prevette, D.M., Evenson, A., Parsadanian, A. Exp. Neurol. (2004) [Pubmed]
  38. Maintenance of mouse male germ line stem cells in vitro. Nagano, M., Ryu, B.Y., Brinster, C.J., Avarbock, M.R., Brinster, R.L. Biol. Reprod. (2003) [Pubmed]
  39. Neurturin, RET, GFRalpha-1 and GFRalpha-2, but not GFRalpha-3, mRNA are expressed in mice gonads. Widenfalk, J., Parvinen, M., Lindqvist, E., Olson, L. Cell Tissue Res. (2000) [Pubmed]
  40. Oral administration of royal jelly facilitates mRNA expression of glial cell line-derived neurotrophic factor and neurofilament H in the hippocampus of the adult mouse brain. Hashimoto, M., Kanda, M., Ikeno, K., Hayashi, Y., Nakamura, T., Ogawa, Y., Fukumitsu, H., Nomoto, H., Furukawa, S. Biosci. Biotechnol. Biochem. (2005) [Pubmed]
  41. Expression of glial cell line-derived neurotrophic factor (GDNF) and GDNF family receptor alpha1 in mouse taste bud cells after denervation. Takeda, M., Suzuki, Y., Obara, N., Uchida, N., Kawakoshi, K. Anatomical science international / Japanese Association of Anatomists. (2005) [Pubmed]
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