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Gene Review

DDIT4L  -  DNA-damage-inducible transcript 4-like

Homo sapiens

Synonyms: DNA damage-inducible transcript 4-like protein, HIF-1 responsive protein RTP801-like, Protein regulated in development and DNA damage response 2, REDD-2, REDD2, ...
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Disease relevance of DDIT4L

  • Treatment of HMDM with desferrioxamine, a molecule that mimics the effect of hypoxia, increased expression of REDD2 in a concentration-dependent fashion [1].

High impact information on DDIT4L

  • In contrast to the findings of that study, here we demonstrate that REDD1, but not REDD2, mRNA expression is dramatically induced following acute dexamethasone treatment both in rat skeletal muscle in vivo and in L6 myoblasts in culture [2].
  • CONCLUSIONS: We showed that stimulation of REDD2 expression in macrophages increases oxLDL-induced cell death, suggesting that REDD2 gene might play an important role in arterial pathology [1].
  • METHODS AND RESULTS: The regulated in development and DNA damage response 2 (REDD2) gene was strongly upregulated as THP-1 macrophages are converted to foam cells [1].
  • Transfection of U-937 and HMEC cells with a REDD2 expression vector increased the sensitivity of the cells for oxLDL-induced cytotoxicity, by inducing a shift from apoptosis toward necrosis [1].

Biological context of DDIT4L


  1. REDD2 gene is upregulated by modified LDL or hypoxia and mediates human macrophage cell death. Cuaz-Pérolin, C., Furman, C., Larigauderie, G., Legedz, L., Lasselin, C., Copin, C., Jaye, M., Searfoss, G., Yu, K.T., Duverger, N., Nègre-Salvayre, A., Fruchart, J.C., Rouis, M. Arterioscler. Thromb. Vasc. Biol. (2004) [Pubmed]
  2. Dexamethasone Represses Signaling through the Mammalian Target of Rapamycin in Muscle Cells by Enhancing Expression of REDD1. Wang, H., Kubica, N., Ellisen, L.W., Jefferson, L.S., Kimball, S.R. J. Biol. Chem. (2006) [Pubmed]
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