Gene Review:
DDIT4 - DNA-damage-inducible transcript 4
Homo sapiens
Synonyms:
DNA damage-inducible transcript 4 protein, Dig2, FLJ20500, HIF-1 responsive protein RTP801, Protein regulated in development and DNA damage response 1, ...
- Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Shoshani, T., Faerman, A., Mett, I., Zelin, E., Tenne, T., Gorodin, S., Moshel, Y., Elbaz, S., Budanov, A., Chajut, A., Kalinski, H., Kamer, I., Rozen, A., Mor, O., Keshet, E., Leshkowitz, D., Einat, P., Skaliter, R., Feinstein, E. Mol. Cell. Biol. (2002)
- REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase. Schwarzer, R., Tondera, D., Arnold, W., Giese, K., Klippel, A., Kaufmann, J. Oncogene (2005)
- Identification of amyloid beta-peptide responsive genes by cDNA microarray technology: involvement of RTP801 in amyloid beta-peptide toxicity. Kim, J.R., Lee, S.R., Chung, H.J., Kim, S., Baek, S.H., Kim, J.H., Kim, Y.S. Exp. Mol. Med. (2003)
- RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation. Malagelada, C., Ryu, E.J., Biswas, S.C., Jackson-Lewis, V., Greene, L.A. J. Neurosci. (2006)
- Inhibition of oxygen-induced retinopathy in RTP801-deficient mice. Brafman, A., Mett, I., Shafir, M., Gottlieb, H., Damari, G., Gozlan-Kelner, S., Vishnevskia-Dai, V., Skaliter, R., Einat, P., Faerman, A., Feinstein, E., Shoshani, T. Invest. Ophthalmol. Vis. Sci. (2004)
- Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway. Lee, M.J., Kim, J.Y., Suk, K., Park, J.H. Mol. Cell. Biol. (2004)
- Dexamethasone Represses Signaling through the Mammalian Target of Rapamycin in Muscle Cells by Enhancing Expression of REDD1. Wang, H., Kubica, N., Ellisen, L.W., Jefferson, L.S., Kimball, S.R. J. Biol. Chem. (2006)
- Sp1-dependent regulation of the RTP801 promoter and its application to hypoxia-inducible VEGF plasmid for ischemic disease. Lee, M., Bikram, M., Oh, S., Bull, D.A., Kim, S.W. Pharm. Res. (2004)
- REDD2 gene is upregulated by modified LDL or hypoxia and mediates human macrophage cell death. Cuaz-Pérolin, C., Furman, C., Larigauderie, G., Legedz, L., Lasselin, C., Copin, C., Jaye, M., Searfoss, G., Yu, K.T., Duverger, N., Nègre-Salvayre, A., Fruchart, J.C., Rouis, M. Arterioscler. Thromb. Vasc. Biol. (2004)
- Induction of a cell stress response gene RTP801 by DNA damaging agent methyl methanesulfonate through CCAAT/enhancer binding protein. Lin, L., Qian, Y., Shi, X., Chen, Y. Biochemistry (2005)
- RTP801 is a novel retinoic acid-responsive gene associated with myeloid differentiation. Gery, S., Park, D.J., Vuong, P.T., Virk, R.K., Muller, C.I., Hofmann, W.K., Koeffler, H.P. Exp. Hematol. (2007)
- Arsenite induces a cell stress-response gene, RTP801, through reactive oxygen species and transcription factors Elk-1 and CCAAT/enhancer-binding protein. Lin, L., Stringfield, T.M., Shi, X., Chen, Y. Biochem. J. (2005)
- Growth control under stress: mTOR regulation through the REDD1-TSC pathway. Ellisen, L.W. Cell Cycle (2005)