Gene Review:
eryC - D-erythrulose-1-phosphate dehydrogenase
Brucella suis 1330
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Disease relevance of eryC
- Analysis of the behavior of eryC mutants of Brucella suis attenuated in macrophages [1].
High impact information on eryC
- Allelic exchange mutants in eryC of Brucella suis were erythritol sensitive in vitro with a MIC of 1 to 5 mM of erythritol [1].
- In vivo, the eryC mutant colonized the spleens of infected BALB/c mice to a significantly lower extent than the wild type and the complemented strain [1].
Associations of eryC with chemical compounds
- Interestingly, eryC mutants that were in addition spontaneously erythritol tolerant nevertheless exhibited wild-type-like intramacrophagic and intramurine replication [1].
References
- Analysis of the behavior of eryC mutants of Brucella suis attenuated in macrophages. Burkhardt, S., Jiménez de Bagüés, M.P., Liautard, J.P., Köhler, S. Infect. Immun. (2005) [Pubmed]
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