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Gene Review

Kcnj4  -  potassium channel, inwardly rectifying...

Rattus norvegicus

Synonyms: BIR11, Brain inwardly rectifying K(+) channel 2, IRK-3, Inward rectifier K(+) channel Kir2.3, Inward rectifier potassium channel 4, ...
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High impact information on Kcnj4

  • In this study, we demonstrate the expression of two inward rectifying K+ channels, IRK1 and IRK3, in adult rat sciatic nerve [1].
  • Inward rectifier K(+) channel Kir2.3 (IRK3) in reactive astrocytes from adult rat brain [2].
  • Moreover, BIR10 and BIR11, two strong rectifier subunits originally cloned from rat brain, exerted subunit-specific sensitivity to quinidine, being much higher for BIR11 [3].

Analytical, diagnostic and therapeutic context of Kcnj4

  • Because a strongly rectifying, inward rectifier K(+) channel with a single-channel conductance of 11-15 pS that is voltage independent is consistent with features of Kir2.3 (IRK3), we performed immunofluorescence experiments with anti-Kir2.3 and anti-glial fibrillary acidic protein antibodies [2].


  1. Inwardly rectifying K+ channels that may participate in K+ buffering are localized in microvilli of Schwann cells. Mi, H., Deerinck, T.J., Jones, M., Ellisman, M.H., Schwarz, T.L. J. Neurosci. (1996) [Pubmed]
  2. Inward rectifier K(+) channel Kir2.3 (IRK3) in reactive astrocytes from adult rat brain. Perillán, P.R., Li, X., Potts, E.A., Chen, M., Bredt, D.S., Simard, J.M. Glia (2000) [Pubmed]
  3. Subunit-specific inhibition of inward-rectifier K+ channels by quinidine. Doi, T., Fakler, B., Schultz, J.H., Ehmke, H., Brändle, U., Zenner, H.P., Süssbrich, H., Lang, F., Ruppersberg, J.P., Busch, A.E. FEBS Lett. (1995) [Pubmed]
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