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Gene Review

Kcnj4  -  potassium inwardly-rectifying channel,...

Mus musculus

Synonyms: IRK-3, IRK3, Inward rectifier K(+) channel Kir2.3, Inward rectifier potassium channel 4, Irk3, ...
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High impact information on Kcnj4

  • IRK1 and IRK3 were restricted to these regions, but they were absent from most parts of the thalamus, cerebellum, and brainstem, where IRK2 was expressed predominantly [1].
  • The amino acid sequence of MB-IRK3 shares 61% and 64% identity to MB-IRK1 and RB-IRK2, respectively [2].
  • We have cloned a novel brain-specific inward rectifier K+ channel from a mouse brain cDNA library and designated it MB-IRK3 [2].
  • Assignment of the murine inwardly rectifying potassium channel IRK3 gene (Kcnj4) to the mouse chromosome 15 [3].
  • The single channel recordings revealed, however, that the unitary conductance of MB-IRKI was approximately 22pS; MB-IRK2, approximately 34pS; and MB-IRK3, approximately 12pS [4].

Anatomical context of Kcnj4


Analytical, diagnostic and therapeutic context of Kcnj4

  • Distribution of IRK2 inwardly rectifying potassium channel mRNA in the mouse brain was studied using in situ hybridization histochemistry and compared with those of other classical inwardly rectifying potassium channel (IRK1 and IRK3) mRNAs [5].


  1. IRK(1-3) and GIRK(1-4) inwardly rectifying K+ channel mRNAs are differentially expressed in the adult rat brain. Karschin, C., Dissmann, E., Stühmer, W., Karschin, A. J. Neurosci. (1996) [Pubmed]
  2. Molecular cloning and functional expression of a novel brain-specific inward rectifier potassium channel. Morishige, K., Takahashi, N., Jahangir, A., Yamada, M., Koyama, H., Zanelli, J.S., Kurachi, Y. FEBS Lett. (1994) [Pubmed]
  3. Assignment of the murine inwardly rectifying potassium channel IRK3 gene (Kcnj4) to the mouse chromosome 15. Morishige, K., Takumi, T., Takahashi, N., Koyama, H., Kurachi, H., Miyake, A., Murata, Y., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Kurachi, Y. Mamm. Genome (1997) [Pubmed]
  4. Molecular and functional heterogeneity of inward rectifier potassium channels in brain and heart. Kurachi, Y., Takahashi, N. J. Card. Fail. (1996) [Pubmed]
  5. Differential distribution of classical inwardly rectifying potassium channel mRNAs in the brain: comparison of IRK2 with IRK1 and IRK3. Horio, Y., Morishige, K., Takahashi, N., Kurachi, Y. FEBS Lett. (1996) [Pubmed]
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