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Cga  -  glycoprotein hormones, alpha polypeptide

Rattus norvegicus

Synonyms: Anterior pituitary glycoprotein hormones common subunit alpha, Cga1, FSH-alpha, Follicle-stimulating hormone alpha chain, Follitropin alpha chain, ...
 
 
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Disease relevance of Cga

 

High impact information on Cga

  • Moreover, perinatal hypothyroid animals demonstrated a dramatic increase in the ratio of sialylated to sulfated species within oligosaccharides of the same negative charge (2.9- to 7.4-fold increase for TSH-alpha; 15.1- to 25.5-fold increase for TSH-beta) [2].
  • The expression of TSH subunit genes (TSH alpha and -beta) in pituitary thyrotropes is primarily regulated via circulating thyroid hormone levels (T3) and the hypothalamic TRH [3].
  • After construction of PT- and PD-specific complementary DNA (cDNA) libraries, the cloning and sequencing of several TSH alpha and -beta subunit clones revealed identical sizes and sequences for the translated and untranslated regions in both hypophyseal compartments [3].
  • The influence of TRH pulse pattern on PRL and TSH alpha- and beta-subunit gene expression was examined in vitro [4].
  • Taken together, these results suggest that 1) both the 65,000 and 82,000 complexes are formed after incremental cross-linking of TSH alpha-beta dimer to receptor subunits; and 2) the TSH receptor may be an oligomer composed of three different subunits, 31,000, 17,000, and 63,000, of which only the 31,000 subunit binds TSH [5].
 

Analytical, diagnostic and therapeutic context of Cga

References

  1. Hormonal regulation of thyrotrophin synthesis and secretion. Ahlquist, J.A., Franklyn, J.A., Wood, D.F., Balfour, N.J., Docherty, K., Sheppard, M.C., Ramsden, D.B. Horm. Metab. Res. Suppl. (1987) [Pubmed]
  2. Changes in the sialylation and sulfation of secreted thyrotropin in congenital hypothyroidism. Gyves, P.W., Gesundheit, N., Thotakura, N.R., Stannard, B.S., DeCherney, G.S., Weintraub, B.D. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  3. Thyrotropin expression in hypophyseal pars tuberalis-specific cells is 3,5,3'-triiodothyronine, thyrotropin-releasing hormone, and pit-1 independent. Bockmann, J., Böckers, T.M., Winter, C., Wittkowski, W., Winterhoff, H., Deufel, T., Kreutz, M.R. Endocrinology (1997) [Pubmed]
  4. Differential actions of thyrotropin (TSH)-releasing hormone pulses in the expression of prolactin and TSH subunit messenger ribonucleic acid in rat pituitary cells in vitro. Haisenleder, D.J., Ortolano, G.A., Dalkin, A.C., Yasin, M., Marshall, J.C. Endocrinology (1992) [Pubmed]
  5. Characterization of the subunit structure of the thyrotropin receptor in the FRTL-5 rat thyroid cell line. Gennick, S.E., Thomas, C.G., Nayfeh, S.N. Endocrinology (1987) [Pubmed]
  6. Comparative effects of food restriction, fasting, diabetes and thyroidectomy on growth hormone and thyrotropin gene expression in the rat pituitary. Rodríguez, M., Rodríguez, F., Jolin, T., Santisteban, P. Eur. J. Endocrinol. (1995) [Pubmed]
 
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