Disease relevance of ART5

• Two new-onset tachycardias occurred, one child developed ART post-surgical ablation of accessory connections and one patient with inducible ventricular tachycardia developed ART 5 years postoperatively [1].

High impact information on ART5

• A combination of different technological approaches reveals that ecto-ARTs are expressed in different tissues with privileged sites such as heart and skeletal muscles for ART1, T lymphocytes for ART2 or testis for ART5 [2].
• The deduced amino acid sequence of ART5 shows 87% sequence identity to its orthologue from the human, and 37 and 32% identity to its murine paralogues ART1 and ART2 [3].
• A single long exon encodes the predicted ART5 catalytic domain [3].
• Northern blot and RT-PCR analyses demonstrate prominent expression of Art5 in testis, and lower levels in cardiac and skeletal muscle [3].

References