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Gene Review

mab21l2  -  mab-21-like 2

Danio rerio

Synonyms: Protein mab-21-like 2, SO:0000704
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High impact information on mab21l2

  • We propose that mab21l2 is an early downstream effector of rx3 and is critical for survival of eye progenitors [1].
  • Their expression profiles revealed that mab21l1 was turned on in embryos as early as 8 h post-fertilization (hpf) while mab21l2 was first detected at around 11 hpf [2].
  • The characteristic expression pattern of mab21l2 facilitates a detailed description of the morphogenesis of the eyes and midbrain in the zebrafish [3].

Biological context of mab21l2


Anatomical context of mab21l2

  • In the midbrain, mab21l2 is expressed in the tectum, and its expression follows the expansion of the tectal region [3].


  1. Zebrafish rx3 and mab21l2 are required during eye morphogenesis. Kennedy, B.N., Stearns, G.W., Smyth, V.A., Ramamurthy, V., van Eeden, F., Ankoudinova, I., Raible, D., Hurley, J.B., Brockerhoff, S.E. Dev. Biol. (2004) [Pubmed]
  2. Expression of zebrafish mab21 genes marks the differentiating eye, midbrain and neural tube. Wong, Y.M., Chow, K.L. Mech. Dev. (2002) [Pubmed]
  3. Zebrafish mab21l2 is specifically expressed in the presumptive eye and tectum from early somitogenesis onwards. Kudoh, T., Dawid, I.B. Mech. Dev. (2001) [Pubmed]
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