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Gene Review:

rx3 - retinal homeobox gene 3

Danio rerio

Synonyms: Retinal homeobox protein Rx3, SO:0000704

Rojas-Muñoz, A. et al., Kennedy, B.N. et al., Loosli, F. et al.

Rojas-Muñoz, Dahm, Nüsslein-Volhard, Kennedy, Stearns, Smyth, Ramamurthy, van Eeden, Ankoudinova, Raible, Hurley, Brockerhoff,

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High impact information on rx3

Loss of Rx3 function in another teleost,medaka, has also been shown to result in an eyeless phenotype.The medaka rx3 locus can fully rescue the zebrafish mutant phenotype [1].
chokh/rx3 specifies the retinal pigment epithelium fate independently of eye morphogenesis [2].
Thus, our data provide the first indication that, in addition to controlling optic lobe evagination and proliferation, chk/rx3 also determines cellular fate [2].
We propose that mab21l2 is an early downstream effector of rx3 and is critical for survival of eye progenitors [3].
Sequence analysis of the chk alleles revealed nonsense or missense mutations in the rx3 homeobox [3].

Analytical, diagnostic and therapeutic context of rx3

Cellular transplantations demonstrate that rx3 function is autonomously required to specify the prospective RPE [2].

References

Loss of eyes in zebrafish caused by mutation of chokh/rx3. Loosli, F., Staub, W., Finger-Baier, K.C., Ober, E.A., Verkade, H., Wittbrodt, J., Baier, H. EMBO Rep. (2003) [Pubmed]
chokh/rx3 specifies the retinal pigment epithelium fate independently of eye morphogenesis. Rojas-Muñoz, A., Dahm, R., Nüsslein-Volhard, C. Dev. Biol. (2005) [Pubmed]
Zebrafish rx3 and mab21l2 are required during eye morphogenesis. Kennedy, B.N., Stearns, G.W., Smyth, V.A., Ramamurthy, V., van Eeden, F., Ankoudinova, I., Raible, D., Hurley, J.B., Brockerhoff, S.E. Dev. Biol. (2004) [Pubmed]

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RAX	Bos taurus
RAX	Canis lupus familiaris
RAX	Gallus gallus
RAX	Homo sapiens
RAX	Macaca mulatta
Rax	Mus musculus
RAX	Pan troglodytes
Rax	Rattus norvegicus
rax	Xenopus (Silurana) tropicalis

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