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Gene Review

Mab21l2  -  mab-21-like 2 (C. elegans)

Mus musculus

Synonyms: Protein mab-21-like 2
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High impact information on Mab21l2

  • It is now known to constitute a family of genes that are highly conserved from vertebrates to invertebrates, and two homologs, Mab21l1 and Mab21l2, have been identified in many species [1].
  • We conclude that Mab21l2 expression is essential for optic vesicle growth and formation of the optic cup, its absence causing reduced expression of Chx10 [2].
  • Developmental expression of Mab21l2 during mouse embryogenesis [3].
  • In addition, Mab21l1 had unique expression in the lens vesicles and genital tubercle whereas Mab21l2 was expressed in the retinal epithelium and umbilical cord [4].
  • This gene, Mab21l2, encodes a transcript with an open reading frame discretely organized in a single exon [5].

Biological context of Mab21l2


Anatomical context of Mab21l2

  • Depletion of Mab21l1 and Mab21l2 messages in mouse embryo arrests axial turning, and impairs notochord and neural tube differentiation [4].

Analytical, diagnostic and therapeutic context of Mab21l2

  • Knockdown of Mab21l2 by antisense morpholino microinjections partially phenocopies the rx3 mutation, leading to microphthalmia, incomplete eye maturation, and dramatic increases in apoptotic eye progenitors [6].


  1. Cell-autonomous involvement of Mab21l1 is essential for lens placode development. Yamada, R., Mizutani-Koseki, Y., Hasegawa, T., Osumi, N., Koseki, H., Takahashi, N. Development (2003) [Pubmed]
  2. Requirement for Mab21l2 during development of murine retina and ventral body wall. Yamada, R., Mizutani-Koseki, Y., Koseki, H., Takahashi, N. Dev. Biol. (2004) [Pubmed]
  3. Developmental expression of Mab21l2 during mouse embryogenesis. Wong, R.L., Chan, K.K., Chow, K.L. Mech. Dev. (1999) [Pubmed]
  4. Depletion of Mab21l1 and Mab21l2 messages in mouse embryo arrests axial turning, and impairs notochord and neural tube differentiation. Wong, R.L., Chow, K.L. Teratology (2002) [Pubmed]
  5. Genomic cloning and chromosomal localization of the mouse Mab21l2 locus. Wong, R.L., Wong, H.T., Chow, K.L. Cytogenet. Cell Genet. (1999) [Pubmed]
  6. Zebrafish rx3 and mab21l2 are required during eye morphogenesis. Kennedy, B.N., Stearns, G.W., Smyth, V.A., Ramamurthy, V., van Eeden, F., Ankoudinova, I., Raible, D., Hurley, J.B., Brockerhoff, S.E. Dev. Biol. (2004) [Pubmed]
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