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Gene Review

Cflar  -  CASP8 and FADD-like apoptosis regulator

Rattus norvegicus

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High impact information on Cflar

  • The expression of two alternative splice variants, Flip and Flop, in mRNAs encoding the four AMPA-selective glutamate receptors (GluR-A, -B, -C, and -D) was studied in the developing brain by in situ hybridization [1].
  • Sensitization of PSC with culture duration was accompanied by increased expression of CD95 and TRAIL receptor 2 and no alterations of Flip expression or protein kinase B phosphorylation but was paralleled by the appearance of a COOH-terminal cleavage product of receptor-interacting protein [2].
  • The expression of eight messenger RNA splice forms encoding the Flip and Flop variants of AMPA receptor subunits GluR-A to -D in the rat lumbar spinal cord was examined by in situ hybridization using specific oligonucleotides [3].
  • The expression level of the mRNAs encoding the Flip and Flop versions of the AMPA-selective glutamate receptor subunits A, B, C and D was studied using in situ hybridization in the hippocampus of rats kindled by Schaffer collateral/commissural fibre stimulation [4].


  1. Glutamate-operated channels: developmentally early and mature forms arise by alternative splicing. Monyer, H., Seeburg, P.H., Wisden, W. Neuron (1991) [Pubmed]
  2. Apoptosis in activated rat pancreatic stellate cells. Klonowski-Stumpe, H., Fischer, R., Reinehr, R., Lüthen, R., Häussinger, D. Am. J. Physiol. Gastrointest. Liver Physiol. (2002) [Pubmed]
  3. Flip and Flop variants of AMPA receptors in the rat lumbar spinal cord. Tölle, T.R., Berthele, A., Zieglgänsberger, W., Seeburg, P.H., Wisden, W. Eur. J. Neurosci. (1995) [Pubmed]
  4. Rat hippocampal kindling induces changes in the glutamate receptor mRNA expression patterns in dentate granule neurons. Kamphuis, W., De Rijk, T.C., Talamini, L.M., Lopes da Silva, F.H. Eur. J. Neurosci. (1994) [Pubmed]
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