Gene Review:
Akt1 - v-akt murine thymoma viral oncogene homolog 1
Rattus norvegicus
Synonyms:
PKB, PKB alpha, Protein kinase B, Protein kinase B alpha, RAC-PK-alpha, ...
- Neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of JNK1/2 via N-methyl-D-aspartate receptor-mediated Akt1 activation. Miao, B., Yin, X.H., Pei, D.S., Zhang, Q.G., Zhang, G.Y. J. Biol. Chem. (2005)
- AKT1 drives endothelial cell membrane asymmetry and microglial activation through Bcl-xL and caspase 1, 3, and 9. Chong, Z.Z., Kang, J.Q., Maiese, K. Exp. Cell Res. (2004)
- Neuroprotective effects of preconditioning ischaemia on ischaemic brain injury through inhibition of mixed-lineage kinase 3 via NMDA receptor-mediated Akt1 activation. Yin, X.H., Zhang, Q.G., Miao, B., Zhang, G.Y. J. Neurochem. (2005)
- Akt promotes increased mammalian cell size by stimulating protein synthesis and inhibiting protein degradation. Faridi, J., Fawcett, J., Wang, L., Roth, R.A. Am. J. Physiol. Endocrinol. Metab. (2003)
- Involvement of oxidative stress in the rapid Akt1 regulating a JNK scaffold during ischemia in rat hippocampus. Pan, J., Pei, D.S., Yin, X.H., Hui, L., Zhang, G.Y. Neurosci. Lett. (2006)
- Activation of protein kinase B (Akt) signaling after electroconvulsive shock in the rat hippocampus. Kang, U.G., Roh, M.S., Jung, J.R., Shin, S.Y., Lee, Y.H., Park, J.B., Kim, Y.S. Prog. Neuropsychopharmacol. Biol. Psychiatry (2004)
- Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Fulton, D., Gratton, J.P., McCabe, T.J., Fontana, J., Fujio, Y., Walsh, K., Franke, T.F., Papapetropoulos, A., Sessa, W.C. Nature (1999)
- Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway. Yano, S., Tokumitsu, H., Soderling, T.R. Nature (1998)
- Resveratrol suppresses angiotensin II-induced Akt/protein kinase B and p70 S6 kinase phosphorylation and subsequent hypertrophy in rat aortic smooth muscle cells. Haider, U.G., Sorescu, D., Griendling, K.K., Vollmar, A.M., Dirsch, V.M. Mol. Pharmacol. (2002)
- Activation of protein kinase B by adenosine A1 and A3 receptors in newborn rat cardiomyocytes. Germack, R., Griffin, M., Dickenson, J.M. J. Mol. Cell. Cardiol. (2004)
- The neuroprotection of insulin on ischemic brain injury in rat hippocampus through negative regulation of JNK signaling pathway by PI3K/Akt activation. Hui, L., Pei, D.S., Zhang, Q.G., Guan, Q.H., Zhang, G.Y. Brain Res. (2005)
- A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification. Pallafacchina, G., Calabria, E., Serrano, A.L., Kalhovde, J.M., Schiaffino, S. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Potentiation of insulin signaling in tissues of Zucker obese rats after acute and long-term treatment with PPARgamma agonists. Jiang, G., Dallas-Yang, Q., Li, Z., Szalkowski, D., Liu, F., Shen, X., Wu, M., Zhou, G., Doebber, T., Berger, J., Moller, D.E., Zhang, B.B. Diabetes (2002)
- Critical role for Akt1 in the modulation of apoptotic phosphatidylserine exposure and microglial activation. Kang, J.Q., Chong, Z.Z., Maiese, K. Mol. Pharmacol. (2003)
- Site-specific detection of S-nitrosylated PKB alpha/Akt1 from rat soleus muscle using CapLC-Q-TOF(micro) mass spectrometry. Lu, X.M., Lu, M., Tompkins, R.G., Fischman, A.J. Journal of mass spectrometry : JMS. (2005)
- Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats. Kim, Y.B., Peroni, O.D., Franke, T.F., Kahn, B.B. Diabetes (2000)
- Brief calorie restriction increases Akt2 phosphorylation in insulin-stimulated rat skeletal muscle. McCurdy, C.E., Davidson, R.T., Cartee, G.D. Am. J. Physiol. Endocrinol. Metab. (2003)
- Elevated myocardial Akt signaling ameliorates doxorubicin-induced congestive heart failure and promotes heart growth. Taniyama, Y., Walsh, K. J. Mol. Cell. Cardiol. (2002)
- Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3. Kim, Y.B., Shulman, G.I., Kahn, B.B. J. Biol. Chem. (2002)
- IGF-I activates the eIF4F system in cardiac muscle in vivo. Vary, T.C., Lang, C.H. Mol. Cell. Biochem. (2005)
- Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load. Reynolds, T.H., Bodine, S.C., Lawrence, J.C. J. Biol. Chem. (2002)
- Tobacco cembranoids protect the function of acute hippocampal slices against NMDA by a mechanism mediated by alpha4beta2 nicotinic receptors. Ferchmin, P.A., Hao, J., Perez, D., Penzo, M., Maldonado, H.M., Gonzalez, M.T., Rodriguez, A.D., de Vellis, J. J. Neurosci. Res. (2005)
- Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: possible role for protein kinase B but not mitogen-activated protein kinase or p70 S6 kinase. Wijkander, J., Landström, T.R., Manganiello, V., Belfrage, P., Degerman, E. Endocrinology (1998)
- The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes. Berwick, D.C., Hers, I., Heesom, K.J., Moule, S.K., Tavare, J.M. J. Biol. Chem. (2002)
- Diazoxide attenuates insulin secretion and hepatic lipogenesis in zucker diabetic fatty rats. Alemzadeh, R., Tushaus, K. Med. Sci. Monit. (2005)
- Sertoli-germ cell anchoring junction dynamics in the testis are regulated by an interplay of lipid and protein kinases. Siu, M.K., Wong, C.H., Lee, W.M., Cheng, C.Y. J. Biol. Chem. (2005)
- K-Ras-mediated increase in cyclooxygenase 2 mRNA stability involves activation of the protein kinase B1. Sheng, H., Shao, J., Dubois, R.N. Cancer Res. (2001)
- Role of phospholipase C-gamma1 in insulin-like growth factor I-induced muscle differentiation of H9c2 cardiac myoblasts. Hong, F., Moon Ka, n.u.l.l., Kim, S.S., Kim, Y.S., Choi, Y.K., Bae, Y.S., Suh, P.G., Ryu, S.H., Choi, E.J., Ha, J., Kim, S.S. Biochem. Biophys. Res. Commun. (2001)
- Insulin increases the association of Akt-2 with Glut4-containing vesicles. Calera, M.R., Martinez, C., Liu, H., Jack, A.K., Birnbaum, M.J., Pilch, P.F. J. Biol. Chem. (1998)
- Integrative mitogenic role of protein kinase B/Akt in beta-cells. Trümper, K., Trümper, A., Trusheim, H., Arnold, R., Göke, B., Hörsch, D. Ann. N. Y. Acad. Sci. (2000)
- The role of protein kinase B and mitogen-activated protein kinase in epidermal growth factor and tumor necrosis factor alpha-mediated rat hepatocyte survival and apoptosis. Roberts, R.A., James, N.H., Cosulich, S.C. Hepatology (2000)
- Involvement of protein kinase B and mitogen-activated protein kinases in experimental normothermic liver ischaemia-reperfusion injury. Cursio, R., Filippa, N., Miele, C., Van Obberghen, E., Gugenheim, J. The British journal of surgery. (2006)
- pERK, pAkt and pBad: A Possible Role in Cell Proliferation and Sustained Cellular Survival During Tumorigenesis and Tumor Progression in ENU Induced Transplacental Glioma Rat Model. Bhaskara, V.K., Sundaram, C., Babu, P.P. Neurochem. Res. (2006)
- Sodium ferulate prevents amyloid-beta-induced neurotoxicity through suppression of p38 MAPK and upregulation of ERK-1/2 and Akt/protein kinase B in rat hippocampus. Jin, Y., Yan, E.Z., Fan, Y., Zong, Z.H., Qi, Z.M., Li, Z. Acta Pharmacol. Sin. (2005)
- FSH activates phosphatidylinositol 3-kinase/protein kinase B signaling pathway in 20-day-old Sertoli cells independently of IGF-I. Meroni, S.B., Riera, M.F., Pellizzari, E.H., Galardo, M.N., Cigorraga, S.B. J. Endocrinol. (2004)
- Two distinct regulatory mechanisms of neurotransmitter release by phosphatidylinositol 3-kinase. Itakura, M., Yamamori, S., Kuwahara, R., Sekiguchi, M., Takahashi, M. J. Neurochem. (2005)