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Gene Review: 

VV1_1977  -  peptidase, insulinase family

Vibrio vulnificus CMCP6

 
 
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Disease relevance of VV1_1977

  • The cloned V. cholerae peptidase processes either EpsI or MshA preproteins when co-expressed in E. coli [1].
  • The type IV leader peptidase/N-methyltransferase of Vibrio vulnificus controls factors required for adherence to HEp-2 cells and virulence in iron-overloaded mice [2].
  • We have cloned and characterized two genes encoding products related to components of the type IV pilus biogenesis and general secretory (type II) pathways by complementation of a type IV peptidase/N-methyltransferase (PilD) mutant of Pseudomonas aeruginosa with a V. vulnificus genomic library [2].
 

High impact information on VV1_1977

  • Mutation of the V. cholerae peptidase gene also results in a defect in virulence and decreased levels of OmpU [1].
  • Plasmid disruption or deletion of this peptidase gene in either EI Tor or classical V. cholerae O1 biotype strains results in a dramatic decrease in cholera toxin secretion [1].
  • The peptidase activity of alpha 2 M-VVP complex was inhibited by low-molecular-weight inhibitors such as phosphoramidon, but IgG antibody against VVP failed to neutralize its peptidase activity [3].

References

  1. Identification of the Vibrio cholerae type 4 prepilin peptidase required for cholera toxin secretion and pilus formation. Marsh, J.W., Taylor, R.K. Mol. Microbiol. (1998) [Pubmed]
  2. The type IV leader peptidase/N-methyltransferase of Vibrio vulnificus controls factors required for adherence to HEp-2 cells and virulence in iron-overloaded mice. Paranjpye, R.N., Lara, J.C., Pepe, J.C., Pepe, C.M., Strom, M.S. Infect. Immun. (1998) [Pubmed]
  3. Inhibitory effect of alpha 2-macroglobulin on Vibrio vulnificus protease. Miyoshi, S., Shinoda, S. J. Biochem. (1989) [Pubmed]
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