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Gene Review

GPR62  -  G protein-coupled receptor 62

Homo sapiens

Synonyms: G-protein coupled receptor GPCR8, G-protein coupled receptor KPG_005, GPCR8, KPG_005, hGPCR8
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High impact information on GPR62

  • A search of the GenBank genomic sequence databases revealed three previously unrecognized intronless genes encoding the orphan GPCrs (oGPCRs) GPR62, GPR63 and GPR77, with respective amino acid lengths of 368, 419 and 337 [1].
  • Sequence analysis revealed that GPR61 and GPR62, and a published orphan receptor p47MNR, shared the highest level of identities to each other, ranging from 36 to 45% in the transmembrane (TM) domains [1].
  • GPR62 mRNA expression was detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus [1].


  1. Identification of four novel human G protein-coupled receptors expressed in the brain. Lee, D.K., George, S.R., Cheng, R., Nguyen, T., Liu, Y., Brown, M., Lynch, K.R., O'Dowd, B.F. Brain Res. Mol. Brain Res. (2001) [Pubmed]
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