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Gene Review:

GPR61 - G protein-coupled receptor 61

Homo sapiens

Synonyms: BALGR, Biogenic amine receptor-like G-protein coupled receptor, GPCR3

Cikos, S. et al., Lee, D.K. et al.

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High impact information on GPR61

Sequence analysis revealed that GPR61 and GPR62, and a published orphan receptor p47MNR, shared the highest level of identities to each other, ranging from 36 to 45% in the transmembrane (TM) domains [1].
GPR61 mRNA expression was detected in the caudate, putamen and thalamus of human brain, with a more widespread expression pattern in rat brain, with mRNA signals in areas of the cortex, hippocampus, thalamus, hypothalamus and midbrain [1].
GPR61 was discovered in a search of the patent literature which retrieved a rabbit DNA sequence partially encoding a novel GPCR [1].
A high level of BALGR transcript is also detected in testes [2].
BALGR gene has been assigned to chromosome 1 by typing a panel of somatic cell hybrids and its exon/intron organization has been predicted [2].

Associations of GPR61 with chemical compounds

We report the cloning and sequence of a novel gene, BALGR, which is coding for a candidate G protein-coupled receptor (GPCR) that is distantly related to the histamine, adrenergic, serotonin and dopamine receptors [2].

Analytical, diagnostic and therapeutic context of GPR61

As determined by semiquantitative RT-PCR, expression of BALGR is relatively the highest in the human brain [2].
BALGR gene has been conserved throughout the mammalian evolution as indicated by Southern blot analysis [2].

References

Identification of four novel human G protein-coupled receptors expressed in the brain. Lee, D.K., George, S.R., Cheng, R., Nguyen, T., Liu, Y., Brown, M., Lynch, K.R., O'Dowd, B.F. Brain Res. Mol. Brain Res. (2001) [Pubmed]
Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed in human brain. Cikos, S., Gregor, P., Koppel, J. Biochim. Biophys. Acta (2001) [Pubmed]

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