Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Ngfrap1 - nerve growth factor receptor (TNFRSF16)...

Mus musculus

Synonyms: AL033356, Bex3, Brain-expressed X-linked protein 3 homolog, DXWsu67e, Gcap27, ...

Kim, A.J. et al., Kendall, S.E. et al., Brown, A.L. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Ngfrap1

Bex3 associates with replicating mitochondria and is involved in possible growth control of F9 teratocarcinoma cells [1].

High impact information on Ngfrap1

Database homology searches revealed two additional uncharacterized cDNAs similar to Bex1 that were named Bex2 and Bex3 [2].
Visualized by deconvolution microscopy as a GFP-fusion protein in F9 teratocarcinoma cells, Bex3 localized, along with concentrations of actin, at perinuclear mitochondria that were undergoing active DNA replication [1].
Bex3 association with mitochondria required a nuclear export signal (NES) and the C-terminal four amino acids (CaaX box), and siRNA reduction of Bex3 levels led to slow or negligible growth rates of the F9 cells [1].
Two such effector proteins, p75NTR-associated cell death executor (NADE) and neurotrophin receptor interacting factor (NRIF) promote p75NTR-mediated apoptosis, whereas Schwann cell factor-1 (SC-1) mediates neurotrophin-dependent withdrawal from the cell cycle [3].

References

Bex3 associates with replicating mitochondria and is involved in possible growth control of F9 teratocarcinoma cells. Kim, A.J., Lee, C.S., Schlessinger, D. Gene (2004) [Pubmed]
Bex1, a gene with increased expression in parthenogenetic embryos, is a member of a novel gene family on the mouse X chromosome. Brown, A.L., Kay, G.F. Hum. Mol. Genet. (1999) [Pubmed]
Characterization of NADE, NRIF and SC-1 gene expression during mouse neurogenesis. Kendall, S.E., Ryczko, M.C., Mehan, M., Verdi, J.M. Brain Res. Dev. Brain Res. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg