Gene Review:
Ngfr - nerve growth factor receptor (TNFR...
Mus musculus
Synonyms:
LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, Tnfrsf16, ...
Culmsee,
Gerling,
Lehmann,
Nikolova-Karakashian,
Prehn,
Mattson,
Krieglstein,
Szutowicz,
Madziar,
Pawełczyk,
Tomaszewicz,
Bielarczyk,
Jiang,
Nyengaard,
Zhang,
Jakobsen,
Zhou,
Li,
Zhou,
Zhong,
Mi,
Wu,
Xian,
Copray,
Küst,
Mantingh-Otter,
Boddeke,
Harada,
Harada,
Nakayama,
Okuyama,
Yoshida,
Kohsaka,
Matsuda,
Wada,
Brennan,
Rivas-Plata,
Landis,
Jiang,
Jakobsen,
- Modification of glial-neuronal cell interactions prevents photoreceptor apoptosis during light-induced retinal degeneration. Harada, T., Harada, C., Nakayama, N., Okuyama, S., Yoshida, K., Kohsaka, S., Matsuda, H., Wada, K. Neuron (2000)
- p53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors. Aloyz, R.S., Bamji, S.X., Pozniak, C.D., Toma, J.G., Atwal, J., Kaplan, D.R., Miller, F.D. J. Cell Biol. (1998)
- Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid-beta peptides via p75NTR/PLAIDD. Hashimoto, Y., Kaneko, Y., Tsukamoto, E., Frankowski, H., Kouyama, K., Kita, Y., Niikura, T., Aiso, S., Bredesen, D.E., Matsuoka, M., Nishimoto, I. J. Neurochem. (2004)
- Effect of p75 neurotrophin receptor antagonist on disease progression in transgenic amyotrophic lateral sclerosis mice. Turner, B.J., Murray, S.S., Piccenna, L.G., Lopes, E.C., Kilpatrick, T.J., Cheema, S.S. J. Neurosci. Res. (2004)
- Characterization of the toxic mechanism triggered by Alzheimer's amyloid-beta peptides via p75 neurotrophin receptor in neuronal hybrid cells. Tsukamoto, E., Hashimoto, Y., Kanekura, K., Niikura, T., Aiso, S., Nishimoto, I. J. Neurosci. Res. (2003)
- A role for p75 receptor in neurotrophin-3 functioning during the development of limb proprioception. Fan, G., Jaenisch, R., Kucera, J. Neuroscience (1999)
- Trks and p75 genes are differentially expressed in the inner ear of human embryos. What may Trks and p75 null mutant mice suggest on human development? Vega, J.A., San José, I., Cabo, R., Rodriguez, S., Represa, J. Neurosci. Lett. (1999)
- Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease. Yaar, M., Zhai, S., Pilch, P.F., Doyle, S.M., Eisenhauer, P.B., Fine, R.E., Gilchrest, B.A. J. Clin. Invest. (1997)
- A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling. Kuruvilla, R., Zweifel, L.S., Glebova, N.O., Lonze, B.E., Valdez, G., Ye, H., Ginty, D.D. Cell (2004)
- Nerve growth factor is an autocrine survival factor for memory B lymphocytes. Torcia, M., Bracci-Laudiero, L., Lucibello, M., Nencioni, L., Labardi, D., Rubartelli, A., Cozzolino, F., Aloe, L., Garaci, E. Cell (1996)
- Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Lee, K.F., Li, E., Huber, L.J., Landis, S.C., Sharpe, A.H., Chao, M.V., Jaenisch, R. Cell (1992)
- Rabies virus glycoprotein (RVG) is a trimeric ligand for the N-terminal cysteine-rich domain of the mammalian p75 neurotrophin receptor. Langevin, C., Jaaro, H., Bressanelli, S., Fainzilber, M., Tuffereau, C. J. Biol. Chem. (2002)
- The role of the p75 neurotrophin receptor in the morphology of dorsal root ganglion cells in streptozotocin diabetic mice: effects of sciatic nerve crush. Jiang, Y., Jakobsen, J. Diabetologia (2004)
- Effects of NGF on acetylcholine, acetyl-CoA metabolism, and viability of differentiated and non-differentiated cholinergic neuroblastoma cells. Szutowicz, A., Madziar, B., Pawełczyk, T., Tomaszewicz, M., Bielarczyk, H. J. Neurochem. (2004)
- Nerve growth factor survival signaling in cultured hippocampal neurons is mediated through TrkA and requires the common neurotrophin receptor P75. Culmsee, C., Gerling, N., Lehmann, M., Nikolova-Karakashian, M., Prehn, J.H., Mattson, M.P., Krieglstein, J. Neuroscience (2002)
- p75NTR independent oligodendrocyte death in cuprizone-induced demyelination in C57BL/6 mice. Copray, J.C., Küst, B.M., Mantingh-Otter, I., Boddeke, H.W. Neuropathol. Appl. Neurobiol. (2005)
- A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human. Buchberg, A.M., Brownell, E., Nagata, S., Jenkins, N.A., Copeland, N.G. Genetics (1989)
- The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Soppet, D., Escandon, E., Maragos, J., Middlemas, D.S., Reid, S.W., Blair, J., Burton, L.E., Stanton, B.R., Kaplan, D.R., Hunter, T. Cell (1991)
- Involvement of transcription factor encoded by the mouse mi locus (MITF) in expression of p75 receptor of nerve growth factor in cultured mast cells of mice. Jippo, T., Morii, E., Tsujino, K., Tsujimura, T., Lee, Y.M., Kim, D.K., Matsuda, H., Kim, H.M., Kitamura, Y. Blood (1997)
- NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR. Mukai, J., Hachiya, T., Shoji-Hoshino, S., Kimura, M.T., Nadano, D., Suvanto, P., Hanaoka, T., Li, Y., Irie, S., Greene, L.A., Sato, T.A. J. Biol. Chem. (2000)
- Molecular profiles of the mouse postnatal development of the esophageal epithelium showing delayed growth start. Daiko, H., Isohata, N., Sano, M., Aoyagi, K., Ogawa, K., Kameoka, S., Yoshida, T., Sasaki, H. Int. J. Mol. Med. (2006)
- TrkB mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor. Glass, D.J., Nye, S.H., Hantzopoulos, P., Macchi, M.J., Squinto, S.P., Goldfarb, M., Yancopoulos, G.D. Cell (1991)
- Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75. Carter, B.D., Kaltschmidt, C., Kaltschmidt, B., Offenhäuser, N., Böhm-Matthaei, R., Baeuerle, P.A., Barde, Y.A. Science (1996)
- The p75 neurotrophin receptor influences NT-3 responsiveness of sympathetic neurons in vivo. Brennan, C., Rivas-Plata, K., Landis, S.C. Nat. Neurosci. (1999)
- Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth. Benson, M.D., Romero, M.I., Lush, M.E., Lu, Q.R., Henkemeyer, M., Parada, L.F. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Selective loss of calcitonin gene-related Peptide-expressing primary sensory neurons of the a-cell phenotype in early experimental diabetes. Jiang, Y., Nyengaard, J.R., Zhang, J.S., Jakobsen, J. Diabetes (2004)
- A TrkA-to-p75NTR molecular switch activates amyloid beta-peptide generation during aging. Costantini, C., Weindruch, R., Della Valle, G., Puglielli, L. Biochem. J. (2005)
- The trk proto-oncogene encodes a receptor for nerve growth factor. Klein, R., Jing, S.Q., Nanduri, V., O'Rourke, E., Barbacid, M. Cell (1991)
- Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR. Rice, F.L., Albers, K.M., Davis, B.M., Silos-Santiago, I., Wilkinson, G.A., LeMaster, A.M., Ernfors, P., Smeyne, R.J., Aldskogius, H., Phillips, H.S., Barbacid, M., DeChiara, T.M., Yancopoulos, G.D., Dunne, C.E., Fundin, B.T. Dev. Biol. (1998)
- Levels of nerve growth factor and neurotrophin-3 are affected differentially by the presence of p75 in sympathetic neurons in vivo. Harrison, S.M., Jones, M.E., Uecker, S., Albers, K.M., Kudrycki, K.E., Davis, B.M. J. Comp. Neurol. (2000)
- Strain-specific complementation between NRIF1 and NRIF2, two zinc finger proteins sharing structural and biochemical properties. Benzel, I., Barde, Y.A., Casademunt, E. Gene (2001)
- c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation. Palmada, M., Kanwal, S., Rutkoski, N.J., Gustafson-Brown, C., Johnson, R.S., Wisdom, R., Carter, B.D., Gufstafson-Brown, C. J. Cell Biol. (2002)
- Notch and NGF/p75NTR control dendrite morphology and the balance of excitatory/inhibitory synaptic input to hippocampal neurones through Neurogenin 3. Salama-Cohen, P., Arévalo, M.A., Grantyn, R., Rodríguez-Tébar, A. J. Neurochem. (2006)
- P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1. Mirnics, Z.K., Yan, C., Portugal, C., Kim, T.W., Saragovi, H.U., Sisodia, S.S., Mirnics, K., Schor, N.F. Neurobiol. Dis. (2005)
- Differential effects of endogenous brain-derived neurotrophic factor on the survival of axotomized sensory neurons in dorsal root ganglia: a possible role for the p75 neurotrophin receptor. Zhou, X.F., Li, W.P., Zhou, F.H., Zhong, J.H., Mi, J.X., Wu, L.L., Xian, C.J. Neuroscience (2005)
- TrkA mediates developmental sympathetic neuron survival in vivo by silencing an ongoing p75NTR-mediated death signal. Majdan, M., Walsh, G.S., Aloyz, R., Miller, F.D. J. Cell Biol. (2001)
- Regional expression of p75NTR contributes to neurotrophin regulation of cerebellar patterning. Carter, A.R., Berry, E.M., Segal, R.A. Mol. Cell. Neurosci. (2003)
- The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death. Bamji, S.X., Majdan, M., Pozniak, C.D., Belliveau, D.J., Aloyz, R., Kohn, J., Causing, C.G., Miller, F.D. J. Cell Biol. (1998)
- Neurotrophin receptor interacting factor (NRIF) is an essential mediator of apoptotic signaling by the p75 neurotrophin receptor. Linggi, M.S., Burke, T.L., Williams, B.B., Harrington, A., Kraemer, R., Hempstead, B.L., Yoon, S.O., Carter, B.D. J. Biol. Chem. (2005)
- A role for p75 neurotrophin receptor in the control of apoptosis-driven hair follicle regression. Botchkarev, V.A., Botchkareva, N.V., Albers, K.M., Chen, L.H., Welker, P., Paus, R. FASEB J. (2000)
- Regulation, cellular localization, and function of the p75 neurotrophin receptor (p75NTR) during the regeneration of facial motoneurons. Gschwendtner, A., Liu, Z., Hucho, T., Bohatschek, M., Kalla, R., Dechant, G., Raivich, G. Mol. Cell. Neurosci. (2003)
- Anterograde axonal transport of BDNF and NT-3 by retinal ganglion cells: roles of neurotrophin receptors. Butowt, R., von Bartheld, C.S. Mol. Cell. Neurosci. (2005)
- Rescue of dorsal root sensory neurons by nerve growth factor and neurotrophin-3, but not brain-derived neurotrophic factor or neurotrophin-4, is dependent on the level of the p75 neurotrophin receptor. Barrett, G.L., Georgiou, A., Reid, K., Bartlett, P.F., Leung, D. Neuroscience (1998)