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Gene Review

NGFRAP1  -  nerve growth factor receptor (TNFRSF16)...

Homo sapiens

Synonyms: BEX3, Bex, Brain-expressed X-linked protein 3, DXS6984E, HGR74, ...
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Disease relevance of NGFRAP1


High impact information on NGFRAP1


Biological context of NGFRAP1

  • Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis [5].
  • Human Bex gene expression was studied with tissue expression arrays probed with specific oligonucleotides [6].
  • We used the yeast two-hybrid system to search for NADE binding protein [1].
  • A major site (nt 4534 to 4733) was present only in a cell line of macrophage/monocyte origin in a region of the genome in which an intragenic enhancer was recently identified (E. Verdin, N. Becker, F. Bex, L. Droogmans, and A. Burny, Proc. Natl. Acad. Sci. USA 87:4874-4878, 1990) [7].
  • Familial inheritance of PI NADE was demonstrated and both PI M2NADE and PI M3NADE phenotypes were observed [8].

Anatomical context of NGFRAP1

  • Human Bex4 is highly expressed in heart, skeletal muscle, and liver, while Bex3 and Bex5 are more widely expressed [6].
  • Expression of NADE in various human cancer cell lines, and human and murine tissues was examined [1].
  • Surgical procedures included Carpentier ring implant (5 patients), Bex posterior annuloplasty (1 patient), implant of artificial chordae (4 patients), papillary muscle reinsertion (2 patients), commissuroplasty (1 patient) and "artificial double orifice" technique (1 patient) [9].
  • The mean freedom rate from tricuspid repair failure (clinical right heart failure, redo annuloplasty, tricuspid valve replacement at follow up) was 95+/-3%, 93+/-3% and 72+/-8% at 5, 10 and 15 years respectively after the De Vega semicircular annuloplasty, and 97+/-1%, 87+/-4% and 66+/-9% after the Bex flexible linear reducer [10].

Associations of NGFRAP1 with chemical compounds


Other interactions of NGFRAP1

  • Furthermore, the cells stably transfected with NADE did not respond to NGF or TNF [1].


  1. NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo. Tong, X., Xie, D., Roth, W., Reed, J., Koeffler, H.P. Int. J. Oncol. (2003) [Pubmed]
  2. Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis. Mukai, J., Shoji, S., Kimura, M.T., Okubo, S., Sano, H., Suvanto, P., Li, Y., Irie, S., Sato, T.A. J. Biol. Chem. (2002) [Pubmed]
  3. NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR. Mukai, J., Hachiya, T., Shoji-Hoshino, S., Kimura, M.T., Nadano, D., Suvanto, P., Hanaoka, T., Li, Y., Irie, S., Greene, L.A., Sato, T.A. J. Biol. Chem. (2000) [Pubmed]
  4. Nerve growth factor-dependent regulation of NADE-induced apoptosis. Mukai, J., Suvant, P., Sato, T.A. Vitam. Horm. (2003) [Pubmed]
  5. Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis. Yoon, K., Jang, H.D., Lee, S.Y. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  6. Characterization of the Bex gene family in humans, mice, and rats. Alvarez, E., Zhou, W., Witta, S.E., Freed, C.R. Gene (2005) [Pubmed]
  7. DNase I-hypersensitive sites are associated with both long terminal repeats and with the intragenic enhancer of integrated human immunodeficiency virus type 1. Verdin, E. J. Virol. (1991) [Pubmed]
  8. A new allele of alpha 1-antitrypsin: PI NADELAIDE. Mulley, J.C., Cox, D.W., Sutherland, G.R. Hum. Genet. (1983) [Pubmed]
  9. Valve repair for traumatic tricuspid regurgitation. Maisano, F., Lorusso, R., Sandrelli, L., Torracca, L., Coletti, G., La Canna, G., Alfieri, O. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (1996) [Pubmed]
  10. Twenty-five years' clinical experience with repair of tricuspid insufficiency. Carrier, M., Pellerin, M., Guertin, M.C., Bouchard, D., Hébert, Y., Perrault, L.P., Cartier, R., Basmadjian, A. The Journal of heart valve disease. (2004) [Pubmed]
  11. Characterization of human dopamine responsive protein DRG-1 that binds to p75NTR-associated cell death executor NADE. Yu, Y., Wang, J., Yuan, H., Qin, F., Wang, J., Zhang, N., Li, Y.Y., Liu, J., Lu, H. Brain Res. (2006) [Pubmed]
  12. Exoenzyme S binds its cofactor 14-3-3 through a non-phosphorylated motif. Hallberg, B. Biochem. Soc. Trans. (2002) [Pubmed]
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