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Gene Review:

NEDD1 - neural precursor cell expressed,...

Homo sapiens

Synonyms: GCP-WD, NEDD-1, Neural precursor cell expressed developmentally down-regulated protein 1, Protein NEDD1, TUBGCP7

Haren, L. et al., Takai, S. et al., Manning, J. et al.

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High impact information on NEDD1

In contrast, NEDD1 can target to the centrosome in the absence of gamma-tubulin [1].
Further, we show that depletion of NEDD1 inhibits centriole duplication, as does depletion of gamma-tubulin [1].
NEDD1-depleted cells show defects in centrosomal microtubule nucleation and form aberrant mitotic spindles with poorly separated poles [1].
In addition, phosphorylation of NEDD1 during mitosis is critical for targeting gamma-tubulin to the spindle, but not the centrosome [2].
Assignment of the developmentally regulated gene NEDD1 to human chromosome 12q22 by fluorescence in situ hybridization [3].

Biological context of NEDD1

We have mapped the human homolog (NEDD1) of the mouse gene to chromosome 12q22 by fluorescence in situ hybridization using R-banded human (pro)metaphase chromosomes [3].

References

NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly. Haren, L., Remy, M.H., Bazin, I., Callebaut, I., Wright, M., Merdes, A. J. Cell Biol. (2006) [Pubmed]
NEDD1: Function in microtubule nucleation, spindle assembly and beyond. Manning, J., Kumar, S. Int. J. Biochem. Cell Biol. (2007) [Pubmed]
Assignment of the developmentally regulated gene NEDD1 to human chromosome 12q22 by fluorescence in situ hybridization. Takai, S., Yoshida, Y., Noda, M., Yamada, K., Kumar, S. Hum. Genet. (1995) [Pubmed]

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