Disease relevance of xylN

• The TOL plasmid pWW0 xylN gene product from Pseudomonas putida is involved in m-xylene uptake [1].

High impact information on xylN

• The apparent K(s) value for the oxidation of m-xylene in intact cells of the xylN mutant was fourfold higher than that of the wild-type strain, although the TOL catabolic enzyme activities in cell extracts from the two strains were almost identical [1].
• In contrast, most of the DNA between xylC and xylN consists of coding sequences [2].
• The last gene of this operon is xylN, which synthesizes a 52-kilodalton polypeptide of unknown function [2].

Associations of xylN with chemical compounds

• To analyze the role of the xylN gene product, xylN on TOL plasmid pWW0 was disrupted by inserting a kanamycin resistance gene, and the phenotypes of P. putida harboring the wild-type and xylN mutant TOL plasmids were characterized [1].

References