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Gene Review:

C4bp - complement component 4 binding protein

Mus musculus

Synonyms: AI195242, C4b-binding protein, C4bpa

van Amerongen, A. et al., Ichihara, C. et al., Nonaka, M.I. et al., Zwirner, J. et al., Kingsmore, S.F. et al., et al.

Nonaka, Hishikawa, Moriyama, Koji, Ogata, Kudo, Kawakami, Nonaka,

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High impact information on C4bp

Using an interspecific cross, gene linkage relationships among members of the murine complement receptor-related genes, C4bp, Cfh, Mcry, and Mcr2, were analyzed by segregation of RFLP in 200 mice [1].
Chromosome localization studies mapped the mouse Daf genes to chromosome 1, where they segregated with the C4-binding protein (C4bp) gene [2].
A chimeric fusion protein encompassing the CD46 ectodomain linked to the C-terminal part of the C4b binding protein (C4bp) alpha chain (sCD46-C4bpalpha) was produced in eukaryotic cells [3].
Increased amounts of C4d, occasionally also of C4b, were paralleled in diseased kidney tissues by distinct deposits of IgM and/or IgG in the presence of C4bp [4].
In similar localization, albeit with distinctly weaker intensity, IgM and C4 binding protein (C4bp) were detected [4].

Biological context of C4bp

Here, we analyze the murine C4bpa gene and show that epididymal and liver C4BPalpha mRNAs are generated from a single-copy gene and that the epididymal C4BPalpha mRNAs are transcribed from novel transcription start sites located approximately 100 base pairs downstream from those used in the liver [5].
A previous study on the genetics of mouse C4-binding protein (C4-bp) indicated the existence of a genetic polymorphism [6].

Anatomical context of C4bp

Passage of mouse EDTA-plasma over an anti-C4-binding protein (anti-C4-bp) affinity column reduced the C4-bp level by an average of 34% and increased the classical C pathway activity as measured with sensitized normal and desialylated sheep erythrocytes, but not versus sensitized rabbit erythrocytes [7].

Associations of C4bp with chemical compounds

They were assessed for their effect on the activation and stability of the cell-bound classical-pathway C3 convertase, EAC14b2a and on the binding of C2 and C4bp to EC4b [8].
This suggests that C-regulation by C4-bp is independent of membrane sialic acid and provides evidence for the presence of a hitherto unknown preferential site for mouse C4-bp on sheep erythrocytes [7].

Physical interactions of C4bp

These results suggest that Ab 242 recognizes an epitope which is closely related to the C2- and C4bp-binding sites in C4b [8].

Other interactions of C4bp

It also interfered with the binding of C4bp to C4b [8].

References

Genetic organization of complement receptor-related genes in the mouse. Kingsmore, S.F., Vik, D.P., Kurtz, C.B., Leroy, P., Tack, B.F., Weis, J.H., Seldin, M.F. J. Exp. Med. (1989) [Pubmed]
Molecular cloning and chromosomal localization of the mouse decay-accelerating factor genes. Duplicated genes encode glycosylphosphatidylinositol-anchored and transmembrane forms. Spicer, A.P., Seldin, M.F., Gendler, S.J. J. Immunol. (1995) [Pubmed]
Octamerization enables soluble CD46 receptor to neutralize measles virus in vitro and in vivo. Christiansen, D., Devaux, P., Réveil, B., Evlashev, A., Horvat, B., Lamy, J., Rabourdin-Combe, C., Cohen, J.H., Gerlier, D. J. Virol. (2000) [Pubmed]
Classical pathway of complement activation in normal and diseased human glomeruli. Zwirner, J., Felber, E., Herzog, V., Riethmüller, G., Feucht, H.E. Kidney Int. (1989) [Pubmed]
Complement C4b-binding protein as a novel murine epididymal secretory protein. Nonaka, M.I., Hishikawa, Y., Moriyama, N., Koji, T., Ogata, R.T., Kudo, A., Kawakami, H., Nonaka, M. Biol. Reprod. (2003) [Pubmed]
Does the mouse C4-binding protein gene (C4BP) map in the H-2 region? Rodríguez de Córdoba, S., Ferreira, A., Rubinstein, P. Immunogenetics (1985) [Pubmed]
Role of C4-binding protein in the defective lysis of sensitized sheep erythrocytes by mouse complement. van Amerongen, A., van Dijk, H., Willers, J.M. Int. Arch. Allergy Appl. Immunol. (1982) [Pubmed]
Monoclonal anti-human C4b antibodies: stabilization and inhibition of the classical-pathway C3 convertase. Ichihara, C., Nakamura, T., Nagasawa, S., Koyama, J. Mol. Immunol. (1986) [Pubmed]

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