High impact information on SLC25A29

• The protein, designated as CACL (CACT-like), is localized to the mitochondria and has palmitoylcarnitine transporting activity [1].
• Thus, CACL may play an important role cooperatively with its homologue CACT in a stress-induced change of lipid metabolism, and may be specialized for the metabolism of a distinct class of fatty acids involved in brain function [1].
• The tissue distribution of CACL is similar to that of CACT; both are expressed at a higher level in tissues using fatty acids as fuels, except in the brain, where only CACL is expressed [1].
• These targets include the inflammatory cells mediating the inflammatory response that generates the hypersecretory phenotype, and highly specific cellular elements such as epidermal growth factor receptor tyrosine kinase and calcium-activated chloride (CACL) channels [2].

Analytical, diagnostic and therapeutic context of SLC25A29

• In addition, CACL is induced by partial hepatectomy or fasting [1].

References