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Chemical Compound Review

Palmitylcarnitine     3-hexadecanoyloxy-4- trimethylammonio...

Synonyms: AGN-PC-00IO3X, CHEMBL301722, AG-E-41385, CHEBI:73067, CHEBI:176953, ...
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Disease relevance of NSC628323


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Chemical compound and disease context of NSC628323


Biological context of NSC628323


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Gene context of NSC628323


Analytical, diagnostic and therapeutic context of NSC628323


  1. Mechanism of arrhythmias induced by palmitylcarnitine in guinea pig papillary muscle. Sakata, K., Hayashi, H., Kobayashi, A., Yamazaki, N. Cardiovasc. Res. (1989) [Pubmed]
  2. Interaction of palmitoylcarnitine with protein kinase C in neuroblastoma NB-2a cells. Sobiesiak-Mirska, J., Nałecz, M.J., Nałecz, K.A. Neurochem. Int. (2003) [Pubmed]
  3. Palmitoylcarnitine, a surface-active metabolite. Goñi, F.M., Requero, M.A., Alonso, A. FEBS Lett. (1996) [Pubmed]
  4. Protective effects of free polyunsaturated fatty acids on arrhythmias induced by lysophosphatidylcholine or palmitoylcarnitine in neonatal rat cardiac myocytes. Kang, J.X., Leaf, A. Eur. J. Pharmacol. (1996) [Pubmed]
  5. The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment. Rufer, A.C., Thoma, R., Benz, J., Stihle, M., Gsell, B., De Roo, E., Banner, D.W., Mueller, F., Chomienne, O., Hennig, M. Structure (2006) [Pubmed]
  6. Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine. Leonardi, R., Rock, C.O., Jackowski, S., Zhang, Y.M. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  7. Substrate proteins for calmodulin-sensitive and phospholipid-sensitive Ca2+-dependent protein kinases in heart, and inhibition of their phosphorylation by palmitoylcarnitine. Katoh, N., Wrenn, R.W., Wise, B.C., Shoji, M., Kuo, J.F. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  8. L-palmitylcarnitine and calcium ions act similarly on excitatory ionic currents in avian ventricular muscle. Inoue, D., Pappano, A.J. Circ. Res. (1983) [Pubmed]
  9. The role of acyltransferases in fatty acid utilization. Borrebaek, B., Christiansen, R., Christophersen, B.O., Bremer, J. Circ. Res. (1976) [Pubmed]
  10. Effect of chronic hypoxia on hepatic triacylglycerol concentration and mitochondrial fatty acid oxidizing capacity in liver and heart. Kinnula, V.L., Hassinen, I. Acta Physiol. Scand. (1978) [Pubmed]
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  12. Increased mitochondrial palmitoylcarnitine/carnitine countertransport by flavone causes oxidative stress and apoptosis in colon cancer cells. Wenzel, U., Nickel, A., Daniel, H. Cell. Mol. Life Sci. (2005) [Pubmed]
  13. Relationship between hepatic mitochondrial functions in vivo and in vitro in rats with carbon tetrachloride-induced liver cirrhosis. Krähenbühl, L., Ledermann, M., Lang, C., Krähenbühl, S. J. Hepatol. (2000) [Pubmed]
  14. Active-site probes of carnitine acyltransferases. Inhibition of carnitine acetyltransferase by hemiacetylcarnitinium, a reaction intermediate analogue. Gandour, R.D., Colucci, W.J., Stelly, T.C., Brady, P.S., Brady, L.J. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  15. Inhibition by palmitoylcarnitine of adhesion and morphological changes in HL-60 cells induced by 12-O-tetradecanoylphorbol-13-acetate. Nakaki, T., Mita, S., Yamamoto, S., Nakadate, T., Kato, R. Cancer Res. (1984) [Pubmed]
  16. Potentiation of free radical-induced lipid peroxidative injury to sarcolemmal membranes by lipid amphiphiles. Mak, I.T., Kramer, J.H., Weglicki, W.B. J. Biol. Chem. (1986) [Pubmed]
  17. In vitro effects of palmitylcarnitine on cardiac plasma membrane Na,K-ATPase, and sarcoplasmic reticulum Ca2+-ATPase and Ca2+ transport. Adams, R.J., Cohen, D.W., Gupte, S., Johnson, J.D., Wallick, E.T., Wang, T., Schwartz, A. J. Biol. Chem. (1979) [Pubmed]
  18. Involvement of protein kinase C in phorbol ester-induced sensitization of HeLa cells to cis-diamminedichloroplatinum(II). Basu, A., Teicher, B.A., Lazo, J.S. J. Biol. Chem. (1990) [Pubmed]
  19. Protection of canine cardiac mitochondrial function by verapamil-cardioplegia during ischemic arrest. Yoon, S.B., McMillin-Wood, J.B., Michael, L.H., Lewis, R.M., Entman, M.L. Circ. Res. (1985) [Pubmed]
  20. Studies on inactivation of pyruvate dehydrogenase by palmitoylcarnitine oxidation in isolated rat heart mitochondria. Hansford, R.G. J. Biol. Chem. (1977) [Pubmed]
  21. Gramicidin-induced enhancement of transbilayer reorientation of lipids in the erythrocyte membrane. Classen, J., Haest, C.W., Tournois, H., Deuticke, B. Biochemistry (1987) [Pubmed]
  22. Carnitine acyltransferase activities in rat brain mitochondria. Bimodal distribution, kinetic constants, regulation by malonyl-CoA and developmental pattern. Bird, M.I., Munday, L.A., Saggerson, E.D., Clark, J.B. Biochem. J. (1985) [Pubmed]
  23. Acyl-CoA chain length affects the specificity of various carnitine palmitoyltransferases with respect to carnitine analogues. Possible application in the discrimination of different carnitine palmitoyltransferase activities. Murthy, M.S., Ramsay, R.R., Pande, S.V. Biochem. J. (1990) [Pubmed]
  24. Tandem mass spectrometric assay for the determination of carnitine palmitoyltransferase II activity in muscle tissue. Rettinger, A., Gempel, K., Hofmann, S., Gerbitz, K.D., Bauer, M.F. Anal. Biochem. (2002) [Pubmed]
  25. Palmitoylcarnitine modulates interaction protein kinase C delta-GAP-43. Sobiesiak-Mirska, J., Nałecz, K.A. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  26. A novel mitochondrial carnitine-acylcarnitine translocase induced by partial hepatectomy and fasting. Sekoguchi, E., Sato, N., Yasui, A., Fukada, S., Nimura, Y., Aburatani, H., Ikeda, K., Matsuura, A. J. Biol. Chem. (2003) [Pubmed]
  27. Inhibition of sodium pump by l-palmitoylcarnitine in single guinea-pig ventricular myocytes. Tanaka, M., Gilbert, J., Pappano, A.J. J. Mol. Cell. Cardiol. (1992) [Pubmed]
  28. Regulation of fatty acid beta-oxidation in rat heart mitochondria. Wang, H.Y., Baxter, C.F., Schulz, H. Arch. Biochem. Biophys. (1991) [Pubmed]
  29. Fatty acid oxidation in mitochondria from needle biopsy samples of human skeletal muscle. Gohil, K., Jones, D.A., Edwards, R.H. Clin. Sci. (1984) [Pubmed]
  30. Influence of the phospholipid n-6/n-3 polyunsaturated fatty acid ratio on the mitochondrial oxidative metabolism before and after myocardial ischemia. Demaison, L., Sergiel, J.P., Moreau, D., Grynberg, A. Biochim. Biophys. Acta (1994) [Pubmed]
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