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Gene Review

Cct2  -  chaperonin containing Tcp1, subunit 2 (beta)

Mus musculus

Synonyms: CCT-beta, Cctb, T-complex protein 1 subunit beta, TCP-1-beta
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High impact information on Cct2

  • In situ hybridization in E11.5 embryos showed that Pcyt1a is expressed ubiquitously, with the highest level in fetal liver, and CCTalpha transcripts are significantly more abundant than transcripts encoding CCTbeta or phosphatidylethanolamine (PtdEtn) N-methyl transferase, two other enzymes capable of producing PtdCho [1].
  • Reduction of the CCTalpha transcripts in heterozygous E11.5 embryos was accompanied by upregulation of CCTbeta and PtdEtn N-methyltransferase transcripts [1].

Analytical, diagnostic and therapeutic context of Cct2

  • In contrast, enzymatic and real-time PCR data revealed that CCTbeta (Pcyt1b) expression is not upregulated to compensate for the reduction in CCTalpha expression in adult liver and other tissues from Pcyt1a+/- heterozygous mice [1].


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