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Gene Review

CCT2  -  Cct2p

Saccharomyces cerevisiae S288c

Synonyms: BIN3, CCT-beta, T-complex protein 1 subunit beta, TCP-1-beta, TCP2, ...
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High impact information on CCT2

  • We have isolated cold-sensitive mutations in two genes of the yeast Saccharomyces cerevisiae, BIN2 and BIN3, that cause aberrant chromosome segregation in vivo [1].
  • We conclude that TCP1 beta supplies an essential function that partially overlaps with that of TCP1 alpha in acting as a molecular chaperone in tubulin and spindle biogenesis [2].


  1. Two yeast genes with similarity to TCP-1 are required for microtubule and actin function in vivo. Chen, X., Sullivan, D.S., Huffaker, T.C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. Primary structure and function of a second essential member of the heterooligomeric TCP1 chaperonin complex of yeast, TCP1 beta. Miklos, D., Caplan, S., Mertens, D., Hynes, G., Pitluk, Z., Kashi, Y., Harrison-Lavoie, K., Stevenson, S., Brown, C., Barrell, B. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
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