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Gene Review:

cysA - sulfate/thiosulfate ABC transporter ATP...

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Nelson, S.O. et al., Hulanicka, M.D. et al., Chin, A.M. et al., Roof, D.M. et al., Miesel, L. et al.

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Disease relevance of cysA

These mutants defined a cluster of genes located between purC and cysA at 50 min on the Salmonella chromosome [1].

High impact information on cysA

Although cysA and crr have been reported to be located on opposite sides of ptsHI, our results suggest that the correct gene order is cysK-ptsHI-crr-cysA [2].
We constructed inversions of the non-permissive intervals trp ('34) to his ('42) and his ('42) to cysA ('50) [3].
The mutations lay in a newly defined gene, termed ptsJ, which mapped on the S. typhimurium chromosome between the ptsHI operon and the cysA gene [4].
The mutant locus responsible for this defect has been designated cysM, and genetic mapping suggests that cysM is very close to and perhaps contiguous with cysA [5].

References

Ethanolamine utilization in Salmonella typhimurium. Roof, D.M., Roth, J.R. J. Bacteriol. (1988) [Pubmed]
Molecular cloning, sequencing, and expression of the crr gene: the structural gene for IIIGlc of the bacterial PEP:glucose phosphotransferase system. Nelson, S.O., Schuitema, A.R., Benne, R., van der Ploeg, L.H., Plijter, J.S., Aan, F., Postma, P.W. EMBO J. (1984) [Pubmed]
Construction of chromosomal rearrangements in Salmonella by transduction: inversions of non-permissive segments are not lethal. Miesel, L., Segall, A., Roth, J.R. Genetics (1994) [Pubmed]
Genetic expression of enzyme I activity of the phosphoenolpyruvate:sugar phosphotransferase system in ptsHI deletion strains of Salmonella typhimurium. Chin, A.M., Sutrina, S., Feldheim, D.A., Saier, M.H. J. Bacteriol. (1987) [Pubmed]
Regulation of O-acetylserine sulfhydrylase B by L-cysteine in Salmonella typhimurium. Hulanicka, M.D., Hallquist, S.G., Kredich, N.M., Mojica-A, T. J. Bacteriol. (1979) [Pubmed]

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