The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

cysM  -  cysteine synthase B

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of cysM


High impact information on cysM

  • The results give a gene order of cysA-cysM-crr-ptsl-ptsH-cysK over a distance of approximately 12 kilobases. cysM and cysA have been cloned and expressed in pBR322; attempts to obtain stable pBR322 derivatives carrying cysK were unsuccessful [2].
  • The enzyme is identical to cysteine synthase B. The intracellular level of this enzyme was regulated by lesser extents of the same factors as those effective for cysteine synthase A [3].
  • Enzymatic proof for the identity of the S-sulfocysteine synthase and cysteine synthase B of Salmonella typhimurium [3].
  • The mutant locus responsible for this defect has been designated cysM, and genetic mapping suggests that cysM is very close to and perhaps contiguous with cysA [4].
  • Since cysM cysK double mutants are cysteine auxotrophs, by selecting for triazole resistance in cysM strains, mutants arising under this condition also should be constitutive for cysteine biosynthesis [5].

Chemical compound and disease context of cysM


Biological context of cysM


Associations of cysM with chemical compounds

  • No difference in the induction of two cysteine biosynthetic enzymes--sulphite reductase and O-acetyl-L-serine sulphydrylase--in wild-type, cysK and cysM strains was observed under aerobic conditions [7].
  • These observations are consistent with the assumption that the observed growth delay of the cysM mutant under anaerobic conditions is the result of abnormalities in the regulation of sulphite reductase [7].
  • Mutants lacking cysteine synthase B were unable to grow on thiosulfate, whereas mutants lacking cysteine synthase A grew on the four inorganic sulfur sources described above with little difference in their growth rates [9].
  • Purification of cysteine synthase B resulted in the copurification of S-sulfocysteine synthase [9].

Other interactions of cysM

  • These activities appear to be associated with the cysM gene, and this is able to be cotransducted with the cysK gene at a high frequency [9].


  1. Identification of a functional homolog of the Escherichia coli and Salmonella typhimurium cysM gene encoding O-acetylserine sulfhydrylase B in Campylobacter jejuni. Garvis, S.G., Tipton, S.L., Konkel, M.E. Gene (1997) [Pubmed]
  2. Cloning and characterization of the cysAMK region of Salmonella typhimurium. Hulanicka, M.D., Garrett, C., Jagura-Burdzy, G., Kredich, N.M. J. Bacteriol. (1986) [Pubmed]
  3. Enzymatic proof for the identity of the S-sulfocysteine synthase and cysteine synthase B of Salmonella typhimurium. Nakamura, T., Iwahashi, H., Eguchi, Y. J. Bacteriol. (1984) [Pubmed]
  4. Regulation of O-acetylserine sulfhydrylase B by L-cysteine in Salmonella typhimurium. Hulanicka, M.D., Hallquist, S.G., Kredich, N.M., Mojica-A, T. J. Bacteriol. (1979) [Pubmed]
  5. Method of isolation of cysteine constitutive mutants of the cysteine regulon in Salmonella typhimurium. Sledziewska, E., Hulanicka, D. Mol. Gen. Genet. (1978) [Pubmed]
  6. Expression of bacterial cysteine biosynthesis genes in transgenic mice and sheep: toward a new in vivo amino acid biosynthesis pathway and improved wool growth. Bawden, C.S., Sivaprasad, A.V., Verma, P.J., Walker, S.K., Rogers, G.E. Transgenic Res. (1995) [Pubmed]
  7. Delayed inducibility of sulphite reductase in cysM mutants of Salmonella typhimurium under anaerobic conditions. Filutowicz, M., Wiater, A., Hulanicka, D. J. Gen. Microbiol. (1982) [Pubmed]
  8. Nucleotide sequence of the region between crr and cysM in Salmonella typhimurium: five novel ORFs including one encoding a putative transcriptional regulator of the phosphotransferase system. Titgemeyer, F., Reizer, J., Reizer, A., Tang, J., Parr, T.R., Saier, M.H. DNA Seq. (1995) [Pubmed]
  9. Evidence that thiosulfate assimilation by Salmonella typhimurium is catalyzed by cysteine synthase B. Nakamura, T., Kon, Y., Iwahashi, H., Eguchi, Y. J. Bacteriol. (1983) [Pubmed]
WikiGenes - Universities