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Gene Review

recD  -  exonuclease V subunit alpha

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

 
 
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Disease relevance of recD

 

High impact information on recD

  • Recipients with mutS and recD mutations overcome this barrier, allowing construction of genetic hybrids [1].
  • Plasmid instability is less severe in recD recJ strains; ColE1 plasmid DNA preparations from these strains show an increased yield of high molecular weight (HMW) linear multimers and a concomitant reduction in plasmid monomers compared to the wild type [2].
 

Biological context of recD

  • In contrast, the inactivation of both mutS and recD results in a synthetic phenotype which substantially increases the time required to cause a lethal infection without changing the LD(50) [1].
 

Other interactions of recD

  • Mutants defective in either mutS or recD do not affect the time course or the 50% lethal dose (LD(50)) of the infection [1].

References

  1. Effect of mutS and recD mutations on Salmonella virulence. Zahrt, T.C., Buchmeier, N., Maloy, S. Infect. Immun. (1999) [Pubmed]
  2. recB recJ mutants of Salmonella typhimurium are deficient in transductional recombination, DNA repair and plasmid maintenance. Garzón, A., Beuzón, C.R., Mahan, M.J., Casadesús, J. Mol. Gen. Genet. (1996) [Pubmed]
 
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