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Gene Review

tolC  -  outer membrane channel protein

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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High impact information on tolC

  • Resistance to other antibiotics, ampicillin, streptomycin, and sulfonamides, was not affected in the acrB and tolC mutants of DT104 strains harboring SGI1 [1].
  • Typhimurium DT204 DeltatolC transductants, concomitant loss of the parC (Ser-80-->Ile) mutation, located approximately 9.3 kb upstream of tolC, resulted in a further 16- to 32-fold decrease in resistance levels to fluoroquinolones and thus a hypersusceptible phenotype (ciprofloxacin MIC of 0.063 mg/L) [2].

Biological context of tolC

  • In the present study we determined, by constructing acrB and tolC mutants, the role of the AcrAB-TolC multidrug efflux system in the multidrug resistance of several DT104 strains displaying additional quinolone resistance or not displaying quinolone resistance [1].


  1. AcrAB-TolC directs efflux-mediated multidrug resistance in Salmonella enterica serovar typhimurium DT104. Baucheron, S., Tyler, S., Boyd, D., Mulvey, M.R., Chaslus-Dancla, E., Cloeckaert, A. Antimicrob. Agents Chemother. (2004) [Pubmed]
  2. Role of TolC and parC mutation in high-level fluoroquinolone resistance in Salmonella enterica serotype Typhimurium DT204. Baucheron, S., Chaslus-Dancla, E., Cloeckaert, A. J. Antimicrob. Chemother. (2004) [Pubmed]
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