The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

fis  -  DNA-binding protein Fis

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of fis

  • Expression of hilA:Tn5lacZY and invF:Tn5lacZY in the fis mutant could be restored by introducing a plasmid containing the S. typhimurium fis gene or a plasmid containing hilD, a gene encoding an AraC-like regulator of Salmonella invasion genes [1].
 

High impact information on fis

  • This decreased expression of hilA and invF resulted in an altered secreted invasion protein profile in the fis mutant [1].
  • A fis mutant of S. enterica serovar Typhimurium showed a ninefold increase in expression from the major rpoS promoter (PrpoS) during exponential growth, whereas expression during SP was unaffected [2].
  • The mutant phenotype can be complemented by wild-type fis carried on a single-copy plasmid [2].
  • Gentamicin protection experiments using bacteria grown to stationary phase prior to infection showed that the ability of the fis mutant strain to replicate within the RAW264.7 macrophage cells was lower than the wild type [3].

References

  1. Fis, a DNA nucleoid-associated protein, is involved in Salmonella typhimurium SPI-1 invasion gene expression. Wilson, R.L., Libby, S.J., Freet, A.M., Boddicker, J.D., Fahlen, T.F., Jones, B.D. Mol. Microbiol. (2001) [Pubmed]
  2. Fis regulates transcriptional induction of RpoS in Salmonella enterica. Hirsch, M., Elliott, T. J. Bacteriol. (2005) [Pubmed]
  3. Fis is required for proper regulation of ssaG expression in Salmonella enterica serovar Typhimurium. Lim, S., Kim, B., Choi, H.S., Lee, Y., Ryu, S. Microb. Pathog. (2006) [Pubmed]
 
WikiGenes - Universities