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Gene Review

fis  -  DNA-binding protein Fis

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of fis

  • Expression of hilA:Tn5lacZY and invF:Tn5lacZY in the fis mutant could be restored by introducing a plasmid containing the S. typhimurium fis gene or a plasmid containing hilD, a gene encoding an AraC-like regulator of Salmonella invasion genes [1].

High impact information on fis

  • This decreased expression of hilA and invF resulted in an altered secreted invasion protein profile in the fis mutant [1].
  • A fis mutant of S. enterica serovar Typhimurium showed a ninefold increase in expression from the major rpoS promoter (PrpoS) during exponential growth, whereas expression during SP was unaffected [2].
  • The mutant phenotype can be complemented by wild-type fis carried on a single-copy plasmid [2].
  • Gentamicin protection experiments using bacteria grown to stationary phase prior to infection showed that the ability of the fis mutant strain to replicate within the RAW264.7 macrophage cells was lower than the wild type [3].


  1. Fis, a DNA nucleoid-associated protein, is involved in Salmonella typhimurium SPI-1 invasion gene expression. Wilson, R.L., Libby, S.J., Freet, A.M., Boddicker, J.D., Fahlen, T.F., Jones, B.D. Mol. Microbiol. (2001) [Pubmed]
  2. Fis regulates transcriptional induction of RpoS in Salmonella enterica. Hirsch, M., Elliott, T. J. Bacteriol. (2005) [Pubmed]
  3. Fis is required for proper regulation of ssaG expression in Salmonella enterica serovar Typhimurium. Lim, S., Kim, B., Choi, H.S., Lee, Y., Ryu, S. Microb. Pathog. (2006) [Pubmed]
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