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Gene Review

cpxA  -  sensory kinase CpxS

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of cpxA

  • In a Salmonella cpxA mutant, the hilA expression level was reduced to less than 10 % of that in the parent strain at pH 6 [1].

High impact information on cpxA

  • Amino acid-sequence comparisons indicate that it belongs to a family of bacterial regulatory proteins including the products of the cpxA, dctB, envZ, ntrB, phoR, phoM, and virA genes [2].
  • The cpxA* mutation, but not the cpxA or the cpxR mutation, significantly reduced the capacity of serotype Typhimurium to adhere to and invade eucaryotic cells, although intracellular replication was not affected [3].
  • Oral vaccination of pigs with an invasive gyrA-cpxA-rpoB Salmonella Typhimurium mutant [4].
  • The potency to protect pigs against colonization and against clinical salmonellosis was evaluated after oral immunization with a live gyrA-cpxA-rpoB Salmonella (S.) Typhimurium mutant (S. Tm. Nal2/Rif9/Rtt) [4].

Biological context of cpxA


  1. Activation of hilA expression at low pH requires the signal sensor CpxA, but not the cognate response regulator CpxR, in Salmonella enterica serovar Typhimurium. Nakayama, S., Kushiro, A., Asahara, T., Tanaka, R., Hu, L., Kopecko, D.J., Watanabe, H. Microbiology (Reading, Engl.) (2003) [Pubmed]
  2. CheA protein, a central regulator of bacterial chemotaxis, belongs to a family of proteins that control gene expression in response to changing environmental conditions. Stock, A., Chen, T., Welsh, D., Stock, J. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  3. Role of the two-component regulator CpxAR in the virulence of Salmonella enterica serotype Typhimurium. Humphreys, S., Rowley, G., Stevenson, A., Anjum, M.F., Woodward, M.J., Gilbert, S., Kormanec, J., Roberts, M. Infect. Immun. (2004) [Pubmed]
  4. Oral vaccination of pigs with an invasive gyrA-cpxA-rpoB Salmonella Typhimurium mutant. Roesler, U., Marg, H., Schröder, I., Mauer, S., Arnold, T., Lehmann, J., Truyen, U., Hensel, A. Vaccine (2004) [Pubmed]
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