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Gene Review

rpoB  -  DNA-directed RNA polymerase subunit beta

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of rpoB


High impact information on rpoB

  • Oral vaccination of pigs with an invasive gyrA-cpxA-rpoB Salmonella Typhimurium mutant [3].
  • These two mutants, which are only marginally affected in their response to Nov, are normally sensitive to Rif and thus might be representative of a new class of rpoB alleles [4].
  • In a subsequent experiment, we found that mutants selected for low-level resistance to Nal include isolates harboring mutations genetically linked to the rpoB locus; of two such mutants studied, one is temperature-sensitive for growth [4].
  • The Rif-resistant and Rif-sensitive rpoB alleles that increase resistance to gyrase inhibitors have one property in common: they all suppress, to varying degrees, the defect in his operon regulation (transcriptional deattenuation) caused by a gyrase defect or inhibition by novobiocin [4].

Biological context of rpoB

  • It is concluded, therefore, that certain rpoB mutations may suppress the DnaA phenotype [2].


  1. Isolation of temperature-sensitive pantothenate kinase mutants of Salmonella typhimurium and mapping of the coaA gene. Dunn, S.D., Snell, E.E. J. Bacteriol. (1979) [Pubmed]
  2. Suppression of the DnaA phenotype by mutations in the rpoB cistron of ribonucleic acid polymerase in Salmonella typhimurium and Escherichia coli. Bagdasarian, M.M., Izakowska, M., Bagdasarian, M. J. Bacteriol. (1977) [Pubmed]
  3. Oral vaccination of pigs with an invasive gyrA-cpxA-rpoB Salmonella Typhimurium mutant. Roesler, U., Marg, H., Schröder, I., Mauer, S., Arnold, T., Lehmann, J., Truyen, U., Hensel, A. Vaccine (2004) [Pubmed]
  4. RNA polymerase (rpoB) mutants selected for increased resistance to gyrase inhibitors in Salmonella typhimurium. Blanc-Potard, A.B., Gari, E., Spirito, F., Figueroa-Bossi, N., Bossi, L. Mol. Gen. Genet. (1995) [Pubmed]
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