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Gene Review:

envZ - osmolarity sensor protein EnvZ

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Pickard, D. et al., Liljeström, P. et al., Kim, C.C. et al., Mills, S.D. et al., Lindgren, S.W. et al.

Kim, Falkow,

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Disease relevance of envZ

The ompB operon, comprising the ompR and envZ genes, was cloned from a Salmonella typhi Ty2 cosmid bank and characterized by DNA sequence analysis [1].

High impact information on envZ

All four insertions were located in the ompR/envZ regulon [2].
The sequence data also showed that ompR and envZ form an operon, where the coding regions overlap by four base-pairs [3].
Analysis of ompR frameshift mutations showed that translation of envZ is almost totally dependent on the translation of the upstream gene ompR [3].
Mutations in envZ and ackA-pta, which disrupted two distinct sources of OmpR phosphorylation, indicated that SPI2 activation by chelators or a shift from rich to acidic minimal medium is largely dependent on functional EnvZ [4].

Biological context of envZ

The S. typhi ompR and envZ genes contained open reading frames encoding proteins of 240 and 451 amino acids, respectively [1].

Anatomical context of envZ

Trafficking of porin-deficient Salmonella typhimurium mutants inside HeLa cells: ompR and envZ mutants are defective for the formation of Salmonella-induced filaments [5].

References

Characterization of defined ompR mutants of Salmonella typhi: ompR is involved in the regulation of Vi polysaccharide expression. Pickard, D., Li, J., Roberts, M., Maskell, D., Hone, D., Levine, M., Dougan, G., Chatfield, S. Infect. Immun. (1994) [Pubmed]
Macrophage killing is an essential virulence mechanism of Salmonella typhimurium. Lindgren, S.W., Stojiljkovic, I., Heffron, F. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
Structure and expression of the ompB operon, the regulatory locus for the outer membrane porin regulon in Salmonella typhimurium LT-2. Liljeström, P., Laamanen, I., Palva, E.T. J. Mol. Biol. (1988) [Pubmed]
Delineation of upstream signaling events in the salmonella pathogenicity island 2 transcriptional activation pathway. Kim, C.C., Falkow, S. J. Bacteriol. (2004) [Pubmed]
Trafficking of porin-deficient Salmonella typhimurium mutants inside HeLa cells: ompR and envZ mutants are defective for the formation of Salmonella-induced filaments. Mills, S.D., Ruschkowski, S.R., Stein, M.A., Finlay, B.B. Infect. Immun. (1998) [Pubmed]

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