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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

malK  -  maltose ABC transporter ATP-binding...

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

 
 
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Disease relevance of malK

  • We have isolated a hybrid gene, composed of the first 455 nucleotides of hisP and nucleotides 275-1107 of malK, the genes coding for the nucleotide-binding components of the high-affinity transport systems for histidine and maltose in Salmonella typhimurium, respectively [1].
  • A strong homology was found between the amino acid sequences, deduced from DNA nucleotide sequences, of cytoplasmic membrane-associated components of the high affinity histidine transport system of Salmonella typhimurium (coded by the hisP gene) and the maltose-maltodextrin transport system of Escherichia coli (coded by the malK gene) [2].
 

High impact information on malK

  • A chimeric nucleotide-binding protein, encoded by a hisP-malK hybrid gene, is functional in maltose transport in Salmonella typhimurium [1].
  • We report on novel mutations in the malK gene of Salmonella enterica serovar Typhimurium, encoding the ATPase subunit of the maltose transporter (MalFGK(2)) [3].
 

Biological context of malK

  • Plasmid pES42-39, harbouring the hybrid gene, was shown to complement only a malK mutation but failed to complement a hisP deletion mutation [1].

References

  1. A chimeric nucleotide-binding protein, encoded by a hisP-malK hybrid gene, is functional in maltose transport in Salmonella typhimurium. Schneider, E., Walter, C. Mol. Microbiol. (1991) [Pubmed]
  2. Extensive homology between membrane-associated components of histidine and maltose transport systems of Salmonella typhimurium and Escherichia coli. Gilson, E., Higgins, C.F., Hofnung, M., Ferro-Luzzi Ames, G., Nikaido, H. J. Biol. Chem. (1982) [Pubmed]
  3. Novel missense mutations that affect the transport function of MalK, the ATP-binding-cassette subunit of the Salmonella enterica serovar typhimurium maltose transport system. Hunke, S., Landmesser, H., Schneider, E. J. Bacteriol. (2000) [Pubmed]
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