Disease relevance of hisP

• We have isolated a hybrid gene, composed of the first 455 nucleotides of hisP and nucleotides 275-1107 of malK, the genes coding for the nucleotide-binding components of the high-affinity transport systems for histidine and maltose in Salmonella typhimurium, respectively [1].

High impact information on hisP

• The level of expression of hisJ is 30-fold greater than that of hisP [2].
• The hisP suppressor mutations behaved similarly to these newly isolated mutations despite the entirely different selection procedure [3].

Biological context of hisP

• Plasmid pES42-39, harbouring the hybrid gene, was shown to complement only a malK mutation but failed to complement a hisP deletion mutation [1].
• We have used this approach to generate a number of mutations in the Salmonella typhimurium hisP gene of the histidine transport operon [4].

References