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Gene Review:

miaB - (dimethylallyl)adenosine tRNA...

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Esberg, B. et al., Hagervall, T.G. et al.

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Disease relevance of miaB

Transcriptional studies revealed two promoters upstream of miaB in E. coli and S. typhimurium [1].

High impact information on miaB

By complementation of the miaB2508::Tn10dCm mutation with a minimal subcloned f474 fragment, we showed that f474 could be identified as the miaB gene, which is transcribed in the counterclockwise direction on the bacterial chromosome [1].
A Rho-independent terminator was identified downstream of the miaB gene, at which the majority (96%) of the miaB transcripts terminate in E. coli, showing that the miaB gene is part of a monocistronic operon [1].
We have used the mutants hisT, miaA and miaB and trmD, which are deficient in the biosynthesis of psi, ms2io6A, and m1G, respectively, to study the functional aspects of the respective modified nucleosides [2].

References

Identification of the miaB gene, involved in methylthiolation of isopentenylated A37 derivatives in the tRNA of Salmonella typhimurium and Escherichia coli. Esberg, B., Leung, H.C., Tsui, H.C., Björk, G.R., Winkler, M.E. J. Bacteriol. (1999) [Pubmed]
Role of tRNA modification in translational fidelity. Hagervall, T.G., Ericson, J.U., Esberg, K.B., Li, J.N., Björk, G.R. Biochim. Biophys. Acta (1990) [Pubmed]

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